Figure 3.

5/6 nephrectomized mice on high-fat, high-cholesterol diet (HFD) have advanced atherosclerotic lesions. Representative cross-sections at aorta root from male LDLr^−/− mice were stained with hematoxylin and eosin (H&E; A and B) and Masson Trichrome (C and D). A and C, control mice on HFD for 24 weeks. B and D, 5/6 nephrectomized (CKD) mice on HFD for 24 weeks. Magnification ×400. The atherosclerotic lesions from CKD mice on HFD had elevated aortic plaque area fraction, luminal narrowing, macrophage filtration, and fibrosis.