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. 2018 Mar 26;293(19):7238–7249. doi: 10.1074/jbc.RA117.000559

Table 1.

Biological characteristics of the four groups of mice

Male mice (n = 6–12/group) were utilized for this study; CTL, control LDLr−/− mice; CKD, 5/6 nephrectomized LDLr−/− mice; LFD, low-fat diet; HFD, high-fat, high-cholesterol diet; BUN, blood urea nitrogen; iPTH, intact parathyroid hormone.

Biological parameters(units) Weeks CTL-LFD CKD-LFD CTL-HFD CKD-HFD
Body weight (g) 0 22.6 ± 0.4 22.2 ± 0.3 22.6 ± 0.3 22.2 ± 0.3
12 32.1 ± 0.9a 27.7 ± 0.4a.b 34.6 ± 0.9a 28.7 ± 0.5a,b
24 34.5 ± 0.9a,b 30.3 ± 0.9a,b 39.3 ± 1.4a 33.1 ± 1.0a,b,c
Systolic blood pressure (mm Hg) 0 103.0 ± 4.9 110.4 ± 4.8 110.4 ± 3.9 111.7 ± 5.4
12 102.7 ± 4.1 99.7 ± 2.4 101.8 ± 4.6 104.0 ± 6.2
24 108.9 ± 4.4 89.70 ± 3.2 108.2 ± 3.4 91.8 ± 4.4
Glycohemoglobin (%) 0 7.1 ± 0.4 6.7 ± 0.2 6.6 ± 0.2 7.0 ± 0.5
24 6.9 ± 0.2 6.5 ± 0.2 6.4 ± 0.1 7.0 ± 0.3
Hematocrit (%) 0 60.8 ± 0.9 57.4 ± 0.7 61.7 ± 0.5 57.1 ± 0.8
12 61.7 ± 0.4 54.0 ± 0.4a,b 59.8 ± 0.5 53.5 ± 0.7a,b
24 59.6 ± 0.7 51.6 ± 0.8a,b 59.0 ± 0.6 51.9 ± 0.8a,b
BUN(mg/dl) 24 29.5 ± 1.5 43.7 ± 1.4b 27.0 ± 1.7 44.7 ± 3.4b
Creatinine (mg/dl) 0 0.06 ± 0.00 0.21 ± 0.01b 0.08 ± 0.00 0.20 ± 0.01b
12 0.08 ± 0.00 0.20 ± 0.01b 0.08 ± 0.03 0.20 ± 0.01b
24 0.12 ± 0.01 0.24 ± 0.02b 0.11 ± 0.01 0.22 ± 0.05b
Calcium (mg/dl) 0 10.4 ± 0.4 9.9 ± 1.1 9.8 ± 0.6 10.1 ± 0.7
24 9.8 ± 0.1 10.5 ± 0.3 10.3 ± 1.0 10.1 ± 0.5
Phosphorus (mg/dl) 0 10.3±.2.5 11.6 ± 3.2 11.7 ± 1.5 11.1 ± 1.0
24 9.7 ± 1.6 9.6 ± 1.1 9.7 ± 1.1 10.1 ± 1.0
Plasma iPTH (pg/ml) 0 336 ± 65 341 ± 124 366 ± 98 368 ± 136
24 314 ± 7 594 ± 8b 329 ± 7 700 ± 6b
Plasma cholesterol (mg/dl) 0 249.2 ± 8.1 281.4 ± 25.5 278.2 ± 11.7 290.1 ± 27.2
12 389.9 ± 212.0 282.8 ± 49.0b 1712 ± 937.4a,c 1478 ± 599.6a,b,c
24 857.7 ± 93.4a 471 ± 53.1a,b 2432 ± 207.8a,c 1532 ± 244.1a,b,c
Plasma triglyceride (mg/dl) 0 198.5 ± 9.8 263.6 ± 17.2 235.4 ± 35.6 216.6 ± 21.9
12 186.4 ± 25.7 412.6 ± 239.2 231.2 ± 79.0 368.3 ± 135.1
24 389.4 ± 66.2a 308 ± 16.8b 1094 ± 147.5a,c 668.2 ± 77.2a,b,c

a p value <0.05 was compared with mice in the same group of different ages.

b p value <0.05 of CKD mice was compared with controls within same diet group.

c p value <0.05 was compared with mice fed low fat diet with similar renal function.

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