Table 1.
Biological characteristics of the four groups of mice
Male mice (n = 6–12/group) were utilized for this study; CTL, control LDLr−/− mice; CKD, 5/6 nephrectomized LDLr−/− mice; LFD, low-fat diet; HFD, high-fat, high-cholesterol diet; BUN, blood urea nitrogen; iPTH, intact parathyroid hormone.
Biological parameters(units) | Weeks | CTL-LFD | CKD-LFD | CTL-HFD | CKD-HFD |
---|---|---|---|---|---|
Body weight (g) | 0 | 22.6 ± 0.4 | 22.2 ± 0.3 | 22.6 ± 0.3 | 22.2 ± 0.3 |
12 | 32.1 ± 0.9a | 27.7 ± 0.4a.b | 34.6 ± 0.9a | 28.7 ± 0.5a,b | |
24 | 34.5 ± 0.9a,b | 30.3 ± 0.9a,b | 39.3 ± 1.4a | 33.1 ± 1.0a,b,c | |
Systolic blood pressure (mm Hg) | 0 | 103.0 ± 4.9 | 110.4 ± 4.8 | 110.4 ± 3.9 | 111.7 ± 5.4 |
12 | 102.7 ± 4.1 | 99.7 ± 2.4 | 101.8 ± 4.6 | 104.0 ± 6.2 | |
24 | 108.9 ± 4.4 | 89.70 ± 3.2 | 108.2 ± 3.4 | 91.8 ± 4.4 | |
Glycohemoglobin (%) | 0 | 7.1 ± 0.4 | 6.7 ± 0.2 | 6.6 ± 0.2 | 7.0 ± 0.5 |
24 | 6.9 ± 0.2 | 6.5 ± 0.2 | 6.4 ± 0.1 | 7.0 ± 0.3 | |
Hematocrit (%) | 0 | 60.8 ± 0.9 | 57.4 ± 0.7 | 61.7 ± 0.5 | 57.1 ± 0.8 |
12 | 61.7 ± 0.4 | 54.0 ± 0.4a,b | 59.8 ± 0.5 | 53.5 ± 0.7a,b | |
24 | 59.6 ± 0.7 | 51.6 ± 0.8a,b | 59.0 ± 0.6 | 51.9 ± 0.8a,b | |
BUN(mg/dl) | 24 | 29.5 ± 1.5 | 43.7 ± 1.4b | 27.0 ± 1.7 | 44.7 ± 3.4b |
Creatinine (mg/dl) | 0 | 0.06 ± 0.00 | 0.21 ± 0.01b | 0.08 ± 0.00 | 0.20 ± 0.01b |
12 | 0.08 ± 0.00 | 0.20 ± 0.01b | 0.08 ± 0.03 | 0.20 ± 0.01b | |
24 | 0.12 ± 0.01 | 0.24 ± 0.02b | 0.11 ± 0.01 | 0.22 ± 0.05b | |
Calcium (mg/dl) | 0 | 10.4 ± 0.4 | 9.9 ± 1.1 | 9.8 ± 0.6 | 10.1 ± 0.7 |
24 | 9.8 ± 0.1 | 10.5 ± 0.3 | 10.3 ± 1.0 | 10.1 ± 0.5 | |
Phosphorus (mg/dl) | 0 | 10.3±.2.5 | 11.6 ± 3.2 | 11.7 ± 1.5 | 11.1 ± 1.0 |
24 | 9.7 ± 1.6 | 9.6 ± 1.1 | 9.7 ± 1.1 | 10.1 ± 1.0 | |
Plasma iPTH (pg/ml) | 0 | 336 ± 65 | 341 ± 124 | 366 ± 98 | 368 ± 136 |
24 | 314 ± 7 | 594 ± 8b | 329 ± 7 | 700 ± 6b | |
Plasma cholesterol (mg/dl) | 0 | 249.2 ± 8.1 | 281.4 ± 25.5 | 278.2 ± 11.7 | 290.1 ± 27.2 |
12 | 389.9 ± 212.0 | 282.8 ± 49.0b | 1712 ± 937.4a,c | 1478 ± 599.6a,b,c | |
24 | 857.7 ± 93.4a | 471 ± 53.1a,b | 2432 ± 207.8a,c | 1532 ± 244.1a,b,c | |
Plasma triglyceride (mg/dl) | 0 | 198.5 ± 9.8 | 263.6 ± 17.2 | 235.4 ± 35.6 | 216.6 ± 21.9 |
12 | 186.4 ± 25.7 | 412.6 ± 239.2 | 231.2 ± 79.0 | 368.3 ± 135.1 | |
24 | 389.4 ± 66.2a | 308 ± 16.8b | 1094 ± 147.5a,c | 668.2 ± 77.2a,b,c |
a p value <0.05 was compared with mice in the same group of different ages.
b p value <0.05 of CKD mice was compared with controls within same diet group.
c p value <0.05 was compared with mice fed low fat diet with similar renal function.