Table 1.

Summary of human α(1,3)-fucosyltransferase substrate specificities based on current literature

The symbols indicate the ability of the enzyme to create the indicated structure with: +, low; ++, moderate; and +++, high potency. The – indicates inability to create the indicated structure, and (+) indicates controversy exists regarding product formation.

FUT	Chromosomal localization	Classification	Ex vivo				Cell line-based
			LeX	sLeX	VIM-2	Di-Fuc-sLeX	LeX	sLeX	VIM-2	Di-Fuc-sLeX
FUT3	19p13.3	Lewis	+	++	NAa	NA	++	++	+	+
FUT4	11q21	Myeloid	+++	+	++	−	++	(+)	+++	−
FUT5	19p13.3	−	+	+	++	NA	+	+	+	+
FUT6	19p13.3	Plasma	++	+++	+	++	++	+++	(+)	+
FUT7	9q34.3	Leukocyte	−	+++	−	++	−	+++	−	+
FUT9	6q16	CNS, PBL	+++	−	+	NA	+++	−	(++)	−

^a NA indicates data not available.