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. 2018 Apr 4;15(6):8223–8230. doi: 10.3892/ol.2018.8417

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Copyright: © Hao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Asiatic acid induces apoptosis and G₂ and S arrest in vitro. (A) Hoechst 33342 nuclear staining showed the efficacy of apoptosis (magnification, ×100). (B) Annexin V/PI dual-immunofluorescence staining of cells treated with asiatic acid for 24 h revealed that the drug significantly increased apoptosis in cells (indicated by Annexin V⁺/PI⁺ cells). (C) Flow cytometry data indicate G2 and M phase arrest in SW480 and HCT116 cells following incubation with asiatic acid for 24 h *P<0.05, **P<0.01, ***P<0.01 vs. control group. All results are expressed as the mean ± standard error. FITC, fluorescein isothiocyanate; PI propidium iodide.