Figure 3.
Validation of cisplatin-resistant ovarian cancer-associated lncRNAs. (A) First the expression levels of dysregulated lncRNAs were validated in cisplatin-resistant and cisplatin-sensitive ovarian cancer tissues, and 8 lncRNAs were dysregulated in cisplatin-resistant ovarian cancer samples compared with cisplatin-sensitive ovarian cancer samples. (B) Subsequently, the expression levels of these 8 lncRNAs were assessed separately in cisplatin-resistant and cisplatin-sensitive ovarian cancer cells. Tissue and cell data demonstrated consistent results. Each experiment was repeated in triplicate. A positive value denotes the dysregulated lncRNAs that are upregulated, and a negative value means dysregulated lncRNAs that are downregulated. Error bars demonstrate that the differences between cisplatin-resistant ovarian cancer and cisplatin-sensitive ovarian cancer were statistically significant. *P<0.05 vs. cisplatin-sensitive ovarian cancer.