Table 2.

Frequency (f) and number (n) of antibody responders (R) and non-responders (NR) to CS peptide repeats for P. vivax, P. falciparum, and P. malariae according to HLA-DRB1 and HLA-DQB1 genotypes

	PvCS		PfCS		PmCS
	R	NR	R	NR	R	NR
	f (n)	f (n)	f (n)	f (n)	f (n)	f (n)
HLA-DRB1
DRB1*01	0.05 (18)	0.15 (30) ***	0.04 (12)	0.13 (36) ***	0.06 (15)	0.11 (33)
DRB1*03	0.06 (23)	0.05 (9)	0.06 (17)	0.05 (15)	0.06 (16)	0.05 (16)
DRB1*04	0.16 (59)	0.15 (29)	0.18 (52)	0.13 (36)	0.14 (35)	0.17 (53)
DRB1*07	0.12 (43)	0.08 (16)	0.13 (36)	0.08 (23)	0.11 (27)	0.10 (32)
DRB1*08	0.07 (27)	0.10 (19)	0.09 (25)	0.08 (21)	0.09 (23)	0.07 (23)
DRB1*09	0.02 (9)	0.03 (6)	0.02 (6)	0.03 (9)	0.02 (6)	0.03 (9)
DRB1*10	0.03 (12)	0.02 (3)	0.01 (4)	0.04 (11)	0.03 (7)	0.03 (8)
DRB1*11	0.11 (40)	0.10 (19)	0.10 (27)	0.12 (32)	0.12 (31)	0.09 (28)
DRB1*12	0.01 (2)	0.03 (5)	0.01 (3)	0.01 (4)	0.01 (3)	0.01 (4)
DRB1*13	0.15 (56)	0.11 (22)	0.15 (41)	0.13 (37)	0.14 (34)	0.14 (44)
DRB1*14	0.04 (16)	0.04 (7)	0.05 (13)	0.04 (10)	0.04 (9)	0.05 (14)
DRB1*15	0.09 (33)	0.10 (19)	0.08 (23)	0.10 (29)	0.10 (26)	0.08 (26)
DRB1*16	0.08 (28)	0.05 (10)	0.08 (23)	0.05 (15)	0.07 (18)	0.06 (20)
HLA-DQB1
DQB1*02	0.17 (62)	0.12 (24)	0.19 (53)*	0.12 (33)	0.17 (43)	0.14 (43)
DQB1*03	0.40 (145)	0.34 (65)	0.41 (116)	0.34 (94)	0.38 (96)	0.37 (114)
DQB1*04	0.08 (30)	0.08 (16)	0.07 (21)	0.09 (25)	0.06 (16)	0.10 (30)
DQB1*05	0.15 (54)	0.24 (47) **	0.13 (36)	0.23 (65) *	0.17 (42)	0.19 (59)
DQB1*06	0.20 (74)	0.22 (42)	0.20 (55)	0.22 (61)	0.21 (52)	0.21 (64)

The association was verified sing a Fisher’s exact test 2 × 2 contingency table; *P < 0.01, ** P < 0.001, *** P < 0.0001. Each individual contributed with two HLA allele observations