Table 2.
Variable | Patients With Adjuvant Therapy |
Unadjusted OR* | 95% CI | P* | Adjusted OR† | 95% CI | P† | |
---|---|---|---|---|---|---|---|---|
No. | % | |||||||
Age at diagnosis, years | ||||||||
< 50 | 300 | 91 | Referent | < .001 | Referent | < .001 | ||
50-64 | 451 | 87 | 0.63 | 0.40 to 0.99 | 0.55 | 0.32 to 0.94 | ||
65-74 | 197 | 79 | 0.36 | 0.22 to 0.59 | 0.22 | 0.10 to 0.47 | ||
75+ | 42 | 45 | 0.08 | 0.05 to 0.14 | 0.04 | 0.02 to 0.10 | ||
ECOG performance status | ||||||||
0 | 843 | 86 | Referent | < .001 | Referent | .002 | ||
1+ | 86 | 68 | 0.35 | 0.23 to 0.53 | 0.40 | 0.24 to 0.68 | ||
Unknown | 61 | 74 | 0.49 | 0.29 to 0.82 | 0.59 | 0.29 to 1.16 | ||
Center | ||||||||
A | 45 | 73 | 0.44 | 0.24 to 0.82 | < .001 | 0.35 | 0.17 to 0.73 | < .001 |
B | 85 | 88 | 1.17 | 0.60 to 2.29 | 1.35 | 0.61 to 2.98 | ||
C | 48 | 84 | 0.88 | 0.41 to 1.90 | 2.19 | 0.79 to 6.06 | ||
D | 298 | 91 | 1.65 | 1.03 to 2.63 | 1.38 | 0.81 to 2.36 | ||
E | 43 | 72 | 0.42 | 0.22 to 0.79 | 0.65 | 0.30 to 1.41 | ||
F | 69 | 58 | 0.23 | 0.14 to 0.36 | 0.27 | 0.15 to 0.48 | ||
G | 338 | 86 | Referent | Referent | ||||
H | 64 | 84 | 0.88 | 0.45 to 1.74 | 0.86 | 0.39 to 1.89 | ||
Insurance | ||||||||
Private | 652 | 90 | Referent | < .001 | Referent | .009 | ||
Medicare | 236 | 72 | 0.29 | 0.21 to 0.41 | 1.42 | 0.72 to 2.80 | ||
Medicaid/indigent | 59 | 69 | 0.25 | 0.15 to 0.42 | 0.35 | 0.19 to 0.67 | ||
Other | 31 | 86 | 0.70 | 0.27 to 1.87 | 0.74 | 0.26 to 2.14 | ||
Unknown | 12 | 71 | 0.27 | 0.09 to 0.80 | 0.90 | 0.24 to 3.43 | ||
Clinical TNM stage | ||||||||
Locally advanced | 37 | 77 | 0.59 | 0.29 to 1.19 | .03 | 0.30 | 0.04 to 2.45 | .26 |
II | 290 | 79 | 0.67 | 0.49 to 0.92 | 0.77 | 0.51 to 1.14 | ||
III | 663 | 85 | Referent | Referent | ||||
Clinical to pathologic TNM stage: was the patient downstaged or upstaged?‡ | ||||||||
Complete responders§ | 190 | 79 | 0.64 | 0.42 to 0.98 | .08 | 0.62 | 0.37 to 0.99 | .03 |
Downstaged | 386 | 83 | 0.86 | 0.59 to 1.26 | 0.84 | 0.54 to 1.31 | ||
Upstaged | 64 | 90 | 1.57 | 0.68 to 3.61 | 2.54 | 0.95 to 6.80 | ||
No Change in stage | 303 | 31 | Referent | Referent | ||||
Re-operation wound infection | ||||||||
No | 955 | 84 | Referent | < .001 | Referent | < .001 | ||
Yes | 35 | 59 | 0.27 | 0.16 to 0.47 | 0.25 | 0.13 to 0.48 | ||
Closure of ileostomy/colostomy | ||||||||
No | 403 | 76 | 0.41 | 0.30 to 0.56 | < .001 | 0.60 | 0.40 to 0.89 | .01 |
Yes | 587 | 89 | Referent | Referent |
Abbreviations: ECOG, Eastern Cooperative Oncology Group; OR, odds ratio.
Unadjusted OR = univariate logistic regression.
Adjusted OR = multivariable logistic regression. The final multivariable logistic regression model has the following factors: age at diagnosis, ECOG performance status, center, insurance, clinical TNM stage, downstaged/upstaged, re-operation of wound infection, and closure of ileostomy/colostomy. Factors that were not significant in the univariate and/or multivariable model were not reported (sex, race/ethnic background, income, histology, grade, Charlson comorbidity score, pathologic TNM stage, lymphovascular invasion, perineural invasion, margin status, distance from and verge, carcinoembryonic antigen, lower anterior resection, abdominoperineal resection, proctectomy, and colostomy).
Sixty-three of the patients were excluded from the downstaged/upstaged analyses, as these patients either had clinical TNM stage or a pathologic TNM stage of locally advanced, but stage of disease not further specified.
Complete responders are patients with pathologic TNM stage 0.