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. 2012 Nov 19;31(1):30–38. doi: 10.1200/JCO.2011.40.3188

Table 2.

Factors Associated With Receiving Adjuvant Therapy for Patients With Stage II/III and Locally Advanced Rectal Cancer

Variable Patients With Adjuvant Therapy
Unadjusted OR* 95% CI P* Adjusted OR 95% CI P
No. %
Age at diagnosis, years
    < 50 300 91 Referent < .001 Referent < .001
    50-64 451 87 0.63 0.40 to 0.99 0.55 0.32 to 0.94
    65-74 197 79 0.36 0.22 to 0.59 0.22 0.10 to 0.47
    75+ 42 45 0.08 0.05 to 0.14 0.04 0.02 to 0.10
ECOG performance status
    0 843 86 Referent < .001 Referent .002
    1+ 86 68 0.35 0.23 to 0.53 0.40 0.24 to 0.68
    Unknown 61 74 0.49 0.29 to 0.82 0.59 0.29 to 1.16
Center
    A 45 73 0.44 0.24 to 0.82 < .001 0.35 0.17 to 0.73 < .001
    B 85 88 1.17 0.60 to 2.29 1.35 0.61 to 2.98
    C 48 84 0.88 0.41 to 1.90 2.19 0.79 to 6.06
    D 298 91 1.65 1.03 to 2.63 1.38 0.81 to 2.36
    E 43 72 0.42 0.22 to 0.79 0.65 0.30 to 1.41
    F 69 58 0.23 0.14 to 0.36 0.27 0.15 to 0.48
    G 338 86 Referent Referent
    H 64 84 0.88 0.45 to 1.74 0.86 0.39 to 1.89
Insurance
    Private 652 90 Referent < .001 Referent .009
    Medicare 236 72 0.29 0.21 to 0.41 1.42 0.72 to 2.80
    Medicaid/indigent 59 69 0.25 0.15 to 0.42 0.35 0.19 to 0.67
    Other 31 86 0.70 0.27 to 1.87 0.74 0.26 to 2.14
    Unknown 12 71 0.27 0.09 to 0.80 0.90 0.24 to 3.43
Clinical TNM stage
    Locally advanced 37 77 0.59 0.29 to 1.19 .03 0.30 0.04 to 2.45 .26
    II 290 79 0.67 0.49 to 0.92 0.77 0.51 to 1.14
    III 663 85 Referent Referent
Clinical to pathologic TNM stage: was the patient downstaged or upstaged?
    Complete responders§ 190 79 0.64 0.42 to 0.98 .08 0.62 0.37 to 0.99 .03
    Downstaged 386 83 0.86 0.59 to 1.26 0.84 0.54 to 1.31
    Upstaged 64 90 1.57 0.68 to 3.61 2.54 0.95 to 6.80
    No Change in stage 303 31 Referent Referent
Re-operation wound infection
    No 955 84 Referent < .001 Referent < .001
    Yes 35 59 0.27 0.16 to 0.47 0.25 0.13 to 0.48
Closure of ileostomy/colostomy
    No 403 76 0.41 0.30 to 0.56 < .001 0.60 0.40 to 0.89 .01
    Yes 587 89 Referent Referent

Abbreviations: ECOG, Eastern Cooperative Oncology Group; OR, odds ratio.

*

Unadjusted OR = univariate logistic regression.

Adjusted OR = multivariable logistic regression. The final multivariable logistic regression model has the following factors: age at diagnosis, ECOG performance status, center, insurance, clinical TNM stage, downstaged/upstaged, re-operation of wound infection, and closure of ileostomy/colostomy. Factors that were not significant in the univariate and/or multivariable model were not reported (sex, race/ethnic background, income, histology, grade, Charlson comorbidity score, pathologic TNM stage, lymphovascular invasion, perineural invasion, margin status, distance from and verge, carcinoembryonic antigen, lower anterior resection, abdominoperineal resection, proctectomy, and colostomy).

Sixty-three of the patients were excluded from the downstaged/upstaged analyses, as these patients either had clinical TNM stage or a pathologic TNM stage of locally advanced, but stage of disease not further specified.

§

Complete responders are patients with pathologic TNM stage 0.