Figure 1.

Upregulation of let-7f-5p is associated with poor chemotherapeutic response in CRC. (A) In the TCGA dataset, let-7f-5p expression levels were markedly higher in CRC patients with a poor chemotherapy response (CR) than those with a favorable chemotherapy response (CS). A Mann-Whitney U test was used to determine statistical differences between two groups. The data are presented as the median ± interquartile range. (B) Percentages and numbers of samples exhibiting high or low let-7f-5p expression with different chemotherapeutic responses in the TCGA dataset. The χ² test was used to determine statistical differences between two groups. CRC, colorectal cancer; TCGA, The Cancer Genome Atlas; CR, chemoresistant; CS, chemosensitive.