Combined (Acu and Sin) curative treatment affects TNF-α, IL-6, IL-1β and IL-8 serum levels in collagen-induced arthritis. Combined curative treatment effects on (A) TNF-α, (B) IL-6, (C) IL-1β and (D) IL-8 serum levels in collagen-induced arthritis. **P<0.01 vs. control group; #P<0.01 vs. arthritis model group, ##P<0.01 vs. arthritis model group. TNF-α, tumor necrosis factor α; IL, interleukin; Acu, acupuncture; Sin, sinomenine.