Combined (Acu and Sin) curative treatment affects COX-2, iNOS, NF-κB and p-p38 protein expression in collagen-induced arthritis. (A) Western blot analysis demonstrating the effect of combined curative treatment on COX-2, iNOS, NF-κB and p-p38 protein expression. (B-E) Quantification of COX-2, iNOS, NF-κB and p-p38 protein expression in collagen-induced arthritis. **P<0.01 compared with control group; #P<0.01 compared with arthritis model group, ##P<0.01 compared with arthritis model group.