Table II.

Univariate and multivariate analysis for the possible predictive factors of OS.

	Univariate analysis		Multivariate analysis
Factor	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (>63 vs. ≤63 years)	1.433 (1.015–2.023)	0.041	3.895 (1.727–8.783)	0.001
ECOG performance status (0 vs. 1)	1.709 (1.050–2.781)	0.006	1.120 (0.562–2.233)	0.697
ECOG performance status (0 vs. 2)	4.137 (0.462–11.707)	0.007	1.913 (0.397–9.206)	0.419
Child-Pugh class (A vs. B)	1.787 (1.018–3.138)	0.043	0.413 (0.157–1.089)	0.074
BCLC stage (B vs. C)	1.290 (0.850–1.958)	0.231
Basal AFP (≤200 vs. >200 ng/ml)	1.583 (1.103–2.272)	0.013	2.694 (0.392–5.212)	0.003
AFP reduction [Responders (>20%) vs. Non-responders (≤20)]	2.032 (1.230–3.357)	0.006	9.723 (2.252–41.969)	0.002

HR, Hazard ratio; CI, confidence interval; AFP, α-fetoprotein; BCLC, Barcelona Clinic Liver Disease; ECOG, Eastern Cooperative Oncology Group Performance.