Table 1.
Genotype frequencies of LMO1 gene polymorphisms and neuroblastoma susceptibility
| Genotype | Guangdong province | Henan province | Combined | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (N=255) |
Controls (N=531) |
Adjusted OR (95% CI) a |
P a | Cases (N=118) |
Controls (N=281) |
Adjusted OR (95% CI) a |
P a | Cases (N=373) |
Controls (N=812) |
Adjusted OR (95% CI) a |
P a | |
| rs2168101 G>T (HWE=0.670) | HWE=0.462 | HWE=0.448 | ||||||||||
| GG | 166 (65.10) | 275 (51.79) | 1.00 | 79 (66.95) | 132 (46.98) | 1.00 | 245 (65.68) | 407 (50.12) | 1.00 | |||
| GT | 82 (32.16) | 217 (40.87) | 0.62 (0.45-0.86) | 0.004 | 35 (29.66) | 125 (44.48) | 0.45 (0.28-0.73) | 0.001 | 117 (31.37) | 342 (42.12) | 0.57 (0.44-0.74) | <0.0001 |
| TT | 7 (2.75) | 39 (7.34) | 0.29 (0.13-0.67) | 0.004 | 4 (3.39) | 24 (8.54) | 0.26 (0.09-0.78) | 0.016 | 11 (2.95) | 63 (7.76) | 0.29 (0.15-0.56) | 0.0002 |
| Additive | 0.59 (0.45-0.77) | 0.0001 | 0.47 (0.32-0.70) | 0.0002 | 0.56 (0.45-0.69) | <0.0001 | ||||||
| Dominant | 89 (34.90) | 256 (48.21) | 0.57 (0.42-0.78) | 0.0004 | 39 (33.05) | 149 (53.02) | 0.42 (0.27-0.66) | 0.0002 | 128 (34.32) | 405 (49.88) | 0.53 (0.41-0.68) | <0.0001 |
| Recessive | 248 (97.25) | 492 (92.66) | 0.35 (0.15-0.80) | 0.012 | 114 (96.61) | 257 (91.46) | 0.36 (0.12-1.05) | 0.062 | 362 (97.05) | 749 (92.24) | 0.36 (0.19-0.69) | 0.002 |
| rs1042359 A>G (HWE=0.065) | HWE=0.199 | HWE=0.786 | ||||||||||
| AA | 233 (91.37) | 485 (91.34) | 1.00 | 97 (82.20) | 224 (79.72) | 1.00 | 330 (88.47) | 709 (87.32) | 1.00 | |||
| AG | 21 (8.24) | 43 (8.10) | 1.02 (0.60-1.76) | 0.947 | 20 (16.95) | 56 (19.93) | 0.82 (0.47-1.44) | 0.491 | 41 (10.99) | 99 (12.19) | 0.89 (0.60-1.31) | 0.547 |
| GG | 1 (0.39) | 3 (0.56) | 0.69 (0.07-6.70) | 0.750 | 1 (0.85) | 1 (0.36) | 2.26 (0.14-36.68) | 0.567 | 2 (0.54) | 4 (0.49) | 1.08 (0.20-5.94) | 0.928 |
| Additive | 0.98 (0.60-1.60) | 0.933 | 0.88 (0.52-1.50) | 0.643 | 0.91 (0.64-1.30) | 0.606 | ||||||
| Dominant | 22 (8.63) | 46 (8.66) | 1.00 (0.59-1.70) | 0.992 | 21 (17.80) | 57 (20.28) | 0.85 (0.49-1.47) | 0.554 | 43 (11.53) | 103 (12.68) | 0.90 (0.61-1.31) | 0.568 |
| Recessive | 254 (99.61) | 528 (99.44) | 0.69 (0.07-6.68) | 0.749 | 117 (99.15) | 280 (99.64) | 2.34 (0.14-37.99) | 0.550 | 371 (99.46) | 808 (99.51) | 1.10 (0.20-6.02) | 0.915 |
| rs11041838 G>C (HWE=0.448) | HWE=0.031 | HWE=0.056 | ||||||||||
| GG | 175 (68.63) | 386 (72.69) | 1.00 | 85 (72.03) | 196 (69.75) | 1.00 | 260 (69.71) | 582 (71.67) | 1.00 | |||
| GC | 74 (29.02) | 136 (25.61) | 1.20 (0.86-1.68) | 0.290 | 31 (26.27) | 83 (29.54) | 0.88 (0.54-1.44) | 0.614 | 105 (28.15) | 219 (26.97) | 1.08 (0.82-1.42) | 0.608 |
| CC | 6 (2.35) | 9 (1.69) | 1.46 (0.51-4.18) | 0.478 | 2 (1.69) | 2 (0.71) | 2.19 (0.30-16.01) | 0.440 | 8 (2.14) | 11 (1.35) | 1.62 (0.65-4.08) | 0.304 |
| Additive | 1.20 (0.90-1.61) | 0.221 | 0.96 (0.61-1.51) | 0.867 | 1.12 (0.88-1.43) | 0.370 | ||||||
| Dominant | 80 (31.37) | 145 (27.31) | 1.22 (0.88-1.68) | 0.243 | 33 (27.97) | 85 (30.25) | 0.92 (0.57-1.48) | 0.719 | 113 (30.29) | 230 (28.33) | 1.10 (0.84-1.44) | 0.483 |
| Recessive | 249 (97.65) | 522 (98.31) | 1.39 (0.49-3.95) | 0.536 | 116 (98.31) | 279 (99.29) | 2.26 (0.31-16.46) | 0.421 | 365 (97.86) | 801 (98.65) | 1.59 (0.63-3.99) | 0.323 |
| rs2071458 C>A (HWE=0.911) | HWE=0.320 | HWE=0.427 | ||||||||||
| CC | 160 (62.75) | 324 (61.02) | 1.00 | 70 (59.32) | 155 (55.16) | 1.00 | 230 (61.66) | 479 (58.99) | 1.00 | |||
| CA | 81 (31.76) | 181 (34.09) | 0.91 (0.66-1.25) | 0.551 | 42 (35.59) | 103 (36.65) | 0.92 (0.58-1.46) | 0.736 | 123 (32.98) | 284 (34.98) | 0.90 (0.69-1.17) | 0.439 |
| AA | 14 (5.49) | 26 (4.90) | 1.13 (0.57-2.22) | 0.733 | 6 (5.08) | 23 (8.19) | 0.58 (0.23-1.50) | 0.264 | 20 (5.36) | 49 (6.03) | 0.85 (0.49-1.47) | 0.560 |
| Additive | 0.98 (0.76-1.26) | 0.843 | 0.84 (0.59-1.19) | 0.331 | 0.91 (0.74-1.12) | 0.375 | ||||||
| Dominant | 95 (37.25) | 207 (38.98) | 0.93 (0.69-1.27) | 0.661 | 48 (40.68) | 126 (44.84) | 0.86 (0.56-1.34) | 0.504 | 143 (38.34) | 333 (41.01) | 0.89 (0.70-1.15) | 0.381 |
| Recessive | 241 (94.51) | 505 (95.10) | 1.17 (0.60-2.28) | 0.656 | 112 (94.92) | 258 (91.81) | 0.60 (0.24-1.52) | 0.283 | 353 (94.64) | 763 (93.97) | 0.88 (0.52-1.51) | 0.649 |
| rs3750952 G>C (HWE=0.994) | HWE=0.763 | HWE=0.886 | ||||||||||
| GG | 147 (57.65) | 253 (47.65) | 1.00 | 65 (55.08) | 120 (42.70) | 1.00 | 212 (56.84) | 373 (45.94) | 1.00 | |||
| GC | 100 (39.22) | 227 (42.75) | 0.76 (0.56-1.03) | 0.081 | 47 (39.83) | 129 (45.91) | 0.66 (0.42-1.03) | 0.069 | 147 (39.41) | 356 (43.84) | 0.73 (0.56-0.94) | 0.014 |
| CC | 8 (3.14) | 51 (9.60) | 0.27 (0.12-0.58) | 0.0008 | 6 (5.08) | 32 (11.39) | 0.32 (0.13-0.81) | 0.017 | 14 (3.75) | 83 (10.22) | 0.30 (0.16-0.53) | <0.0001 |
| Additive | 0.65 (0.50-0.83) | 0.0006 | 0.61 (0.43-0.87) | 0.006 | 0.64 (0.52-0.78) | <0.0001 | ||||||
| Dominant | 108 (42.35) | 278 (52.35) | 0.67 (0.49-0.90) | 0.008 | 53 (44.92) | 161 (57.30) | 0.59 (0.38-0.91) | 0.018 | 161 (43.16) | 439 (54.06) | 0.65 (0.50-0.83) | 0.0005 |
| Recessive | 247 (96.86) | 480 (90.40) | 0.30 (0.14-0.64) | 0.002 | 112 (94.92) | 249 (88.61) | 0.39 (0.16-0.97) | 0.043 | 359 (96.25) | 729 (89.78) | 0.34 (0.19-0.61) | 0.0003 |
| Combined effect of protective genotypes c | ||||||||||||
| 0-1 | 129 (50.59) | 218 (41.05) | 1.00 | 55 (46.61) | 89 (31.67) | 1.00 | 184 (49.33) | 307 (37.81) | 1.00 | |||
| 2-5 | 126 (49.41) | 313 (58.95) | 0.68 (0.50-0.92) | 0.012 | 63 (53.39) | 192 (68.33) | 0.53 (0.34-0.83) | 0.005 | 189 (50.67) | 505 (62.19) | 0.62 (0.49-0.80) | 0.0002 |
OR, odds ratio; CI, confidence interval, HWE, Hardy-Weinberg equilibrium.
a χ2 test for genotype distributions between neuroblastoma patients and controls.
b Adjusted for age and gender.
c Protective genotypes that reduced neuroblastoma risk were rs2168101 GT/TT, rs1042359 AG/GG, rs11041838 GG, rs2071458 CA/AA, and rs3750952 GC/CC.