Table 3.
False-positive report probability results for outstanding findings in combined subjects
| Genotype | Crude OR (95% CI) |
P a | Statistical power b | Prior probability | ||||
|---|---|---|---|---|---|---|---|---|
| 0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
| rs2168101 G>T | ||||||||
| GT vs. GG | 0.57 (0.44-0.74) | <0.0001 | 0.122 | 0.001 | 0.002 | 0.020 | 0.170 | 0.672 |
| TT vs. GG | 0.29 (0.15-0.56) | 0.0002 | 0.009 | 0.060 | 0.160 | 0.677 | 0.955 | 0.995 |
| GT/TT vs. GG | 0.53 (0.41-0.68) | <0.0001 | 0.034 | 0.000 | 0.000 | 0.002 | 0.020 | 0.166 |
| TT vs. GG/GT | 0.36 (0.19-0.69) | 0.0022 | 0.050 | 0.117 | 0.284 | 0.814 | 0.978 | 0.998 |
| GT/TT vs. GG | ||||||||
| >18 | 0.47 (0.34-0.64) | <0.0001 | 0.015 | 0.000 | 0.001 | 0.016 | 0.137 | 0.614 |
| Females | 0.44 (0.30-0.66) | <0.0001 | 0.023 | 0.007 | 0.021 | 0.188 | 0.700 | 0.959 |
| Males | 0.60 (0.43-0.83) | 00.0021 | 0.247 | 0.025 | 0.071 | 0.457 | 0.895 | 0.988 |
| Adrenal gland | 0.41 (0.28-0.61) | <0.0001 | 0.011 | 0.003 | 0.010 | 0.100 | 0.529 | 0.918 |
| Mediastinum | 0.48 (0.31-0.73) | 0.0006 | 0.065 | 0.027 | 0.078 | 0.482 | 0.904 | 0.989 |
| I+II+4s | 0.60 (0.42-0.84) | 0.0032 | 0.258 | 0.036 | 0.100 | 0.551 | 0.925 | 0.992 |
| III+IV | 0.49 (0.35-0.69) | <0.0001 | 0.039 | 0.002 | 0.007 | 0.068 | 0.422 | 0.880 |
| rs3750952 G>C | ||||||||
| GC vs. GG | 0.73 (0.56-0.94) | 0.0143 | 0.743 | 0.055 | 0.148 | 0.656 | 0.951 | 0.995 |
| CC vs. GG | 0.30 (0.16-0.54) | <0.0001 | 0.007 | 0.023 | 0.065 | 0.434 | 0.886 | 0.987 |
| GC/CC vs. GG | 0.65 (0.50-0.83) | 0.0005 | 0.387 | 0.004 | 0.012 | 0.116 | 0.569 | 0.930 |
| CC vs. GG/GC | 0.34 (0.19-0.61) | 0.0003 | 0.022 | 0.038 | 0.107 | 0.567 | 0.930 | 0.993 |
| GC/CC vs. GG | ||||||||
| >18 | 0.55 (0.41-0.75) | 0.0002 | 0.118 | 0.004 | 0.013 | 0.124 | 0.589 | 0.935 |
| Females | 0.63 (0.43-0.92) | 0.0163 | 0.370 | 0.117 | 0.284 | 0.813 | 0.978 | 0.998 |
| Males | 0.66 (0.48-0.91) | 0.0117 | 0.461 | 0.071 | 0.186 | 0.715 | 0.962 | 0.996 |
| Adrenal gland | 0.63 (0.44-0.91) | 0.0138 | 0.374 | 0.100 | 0.249 | 0.785 | 0.974 | 0.997 |
| Mediastinum | 0.46 (0.30-0.69) | 0.0002 | 0.040 | 0.016 | 0.046 | 0.345 | 0.841 | 0.982 |
| I+II+4s | 0.70 (0.50-0.98) | 0.037 | 0.598 | 0.157 | 0.358 | 0.860 | 0.984 | 0.998 |
| III+IV | 0.61 (0.44-0.84) | 0.0025 | 0.290 | 0.025 | 0.072 | 0.461 | 0.896 | 0.989 |
| 2-5 vs. 0-1 | 0.62 (0.49-0.80) | 0.0002 | 0.294 | 0.002 | 0.006 | 0.063 | 0.403 | 0.871 |
| >18 | 0.58 (0.43-0.79) | 0.0005 | 0.184 | 0.008 | 0.025 | 0.220 | 0.740 | 0.966 |
| Females | 0.55 (0.38-0.81) | 0.0025 | 0.168 | 0.042 | 0.117 | 0.593 | 0.936 | 0.993 |
| Males | 0.68 (0.49-0.94) | 0.0206 | 0.542 | 0.103 | 0.256 | 0.791 | 0.974 | 0.997 |
| Adrenal gland | 0.69 (0.47-0.99) | 0.0438 | 0.551 | 0.193 | 0.418 | 0.888 | 0.988 | 0.999 |
| Mediastinum | 0.38 (0.25-0.58) | <0.0001 | 0.005 | 0.003 | 0.008 | 0.080 | 0.466 | 0.897 |
| I+II+4s | 0.62 (0.45-0.87) | 0.0060 | 0.341 | 0.050 | 0.136 | 0.634 | 0.946 | 0.994 |
| III+IV | 0.66 (0.48-0.90) | 0.0092 | 0.446 | 0.057 | 0.155 | 0.668 | 0.953 | 0.995 |
OR, odds ratio; CI, confidence interval.
a Chi-square test was used to calculate the genotype frequency distributions.
b Statistical power was calculated using the number of observations in the subgroup and the OR and P values in this table.