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. 2018 May 8;4(1):e000662. doi: 10.1136/rmdopen-2018-000662

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Patients included in linear extrapolation and observed/last observation carried forward analyses at week 48. Patients who were rescued or discontinued in RA-BEYOND were defined as non-responders. Missing scores and scores obtained after rescue or discontinuation were analysed using both LE and observed/LOCF. *LE imputations were performed for patients who had non-missing values at Week 48 but had been rescued before week 48 or switched at week 24 (placebo responders). If a patient fit into more than one reason, the reason with the earliest date was used. **This value represents all patients with a missing value at week 48 including those who did not enter RA-BEYOND. LE, linear extrapolation; LOCF, last observation carried forward; mITT, modified intent-to-treat; mTSS, modified Total Sharp Score; n, number of mITT patients; n, number of patients included in the analysis (with baseline and at least one postbaseline X-ray available for analysis); QD, once daily; RA, rheumatoid arthritis.