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. 2018 May 8;4(1):e000662. doi: 10.1136/rmdopen-2018-000662

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Inhibition of radiographic progression of structural joint damage at weeks 24 and 48. (Panels A–D) The LSM change from baseline in structural joint damage evaluated using mTSS, joint space narrowing and erosion score. (Panels E and F)Change from baseline in structural joint damage evaluated using the cumulative percentile change in mTSS. *P≤0.05, **P≤0.01, ***P≤0.001 versus placebo. ^†These patients were initially randomised to placebo but switched to baricitinib 4 mg at rescue or at week 24 prior to entry to RA-BEYOND. LSM, least squares mean; mTSS, modified Total Sharp Score.