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. 2018 Apr;13(4):677–683. doi: 10.4103/1673-5374.230294

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Microglia expressed ROCK2, and the ROCK inhibitors were not cytotoxic to cultured spinal cord microglia at the concentrations used.

(A1) CD11b + DAPI double staining; (A2) ROCK2 + DAPI double staining; (A3) CD11b + ROCK2 double staining. Scale bar: 25 μm. (B) Mean LDH release after 1, 3 and 6 hours of treatment with Y27632 (10 μM), fasudil (41 μM) or control (phosphate-buffered saline). (C) ROCK activity in microglia after Y27632 (10 μM) and fasudil (41 μM) treatment. Data are shown as the mean ± SEM (n = 4; one-way analysis of variance followed by Tukey's post hoc test). **P < 0.01. ROCK: Rho-associated kinase; LDH: lactate dehydrogenase; DAPI: 4′,6-diamidino-2-phenylindole.