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. 2018 Apr;13(4):677–683. doi: 10.4103/1673-5374.230294

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Copyright: © Neural Regeneration Research

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The ERK signaling pathway is involved in the morphological changes induced by Y27632 and fasudil in microglia.

Fluorescence double staining (Olympus DP50) with anti-IBA1 (red)/DAPI (blue) shows morphological changes in microglia after a 1-hour treatment with control (A, PBS), Y27632 (B, 10 μM), fasudil (C, 41 μM), U0126 (D, 10 μM), Y27632 (10 μM) + U0126 (10 μM) (E), and fasudil (41 μM) + U0126 (10 μM) (F). Scale bar: 25 μm. ERK: Extracellular signal-regulated kinase; DAPI: 4′,6-diamidino-2-phenylindole.