Figure 6.

rhVEGF-C improved memory deficits in APP/PS1 transgenic mice.

The mean escape latency (A), swimming path (B) and mean swimming velocity of APP/PS1 transgenic mice. Two-way repeated measures analysis of variance followed by the Bonferroni post-hoc test; *P < 0.05, **P < 0.01, vs. control group. Data show the mean number of platform area crossings (D) and time spent in the target quadrant (E) in the probe trial on day 6. Levels of Aβ oligomers were quantified by enzyme-linked immunosorbent assay kits. Data are presented as the mean ± SEM (n = 10 mice; two-tailed Student's t-test). *P < 0.05, **P < 0.01, vs. control group. rhVEGF-C: Recombinant human vascular endothelial growth factor-C; Aβ: amyloid-β.