Figure 1.

Curcumin is a sensitive fluorochrome for AD diagnosis.

(A) Curcumin derivatives for PET imaging. [¹⁸F] fluoropropyl-substituted curcumin, Ki = 0.07 nM to Aβ (Ryu et al., 2006); ¹⁸F-curcumin derivative (Rokka et al., 2014). (B) Curcumin analogue CRANAD-28 for two-photon microscopy imaging (Zhang et al., 2014). Aβ₄₀ monomers: Kd = 68.80 nM, Aβ₄₂ monomers: Kd = 159.70 nM, Aβ₄₂ dimers: Kd = 162.90 nM, Aβ₄₂ oligomers: Kd = 85.70 nM, Aβ₄₀ aggregates: Kd = 52.40 nM. (C) Curcumin analogue FMeC1 for magnetic resonance imaging (Yanagisawa et al., 2011). (D) Curcumin analogues for near-infrared fluorescence imaging. CRANAD-1, Kd =38.00 nM; CRANAD-58, Aβ₄₀: Kd = 105.80 nM, Aβ₄₂: Kd = 45.80 nM; CRANAD-3, Aβ₄₀ monomers: Kd = 24.00 nM, Aβ₄₂ monomers: Kd = 23.00 nM (Ran et al., 2009; Zhang et al., 2013, 2015). AD: Alzheimer's disease; Aβ: amyloid-β; PET: positron emission tomography.