Table 2.
Univariate Cox Proportional Hazard Regression of Clinical Data and HRQoL Scores.
| Variables | Unit of Increase | HR | 95% CI | P Value |
|---|---|---|---|---|
| ECOG | ECOG ≤1 | |||
| ≥2 | 1.436 | 0.837-2.463 | .189 | |
| Site of primary tumor | Colon | .115 | ||
| Rectum | 1.741 | 0.901-3.367 | .099 | |
| Both colon and rectum | 0.706 | 0.324-1.538 | .380 | |
| Number of distant metastatic sites >1 | Number of distant metastatic sites equal to 1 | 1.677 | 0.861-3.267 | .128 |
| Presence of liver metastasis | No presence of liver metastasis | 1.671 | 0.963-2.898 | .068 |
| Previous treatment history | No previous treatment history | 0.860 | 0.339-2.183 | .751 |
| Previous operation history | No previous operation history | 0.930 | 0.465-1.860 | .837 |
| Previous chemotherapy history | No previous chemotherapy history | 1.359 | 0.613-3.011 | .450 |
| Previous radiotherapy history | No previous radiotherapy history | 1.505 | 0.799-2.835 | .206 |
| Number of received chemotherapy regimens ≥2 | Number of received chemotherapy regimen equal to 1 | 1.217 | 0.626-2.369 | .562 |
| Presence of stoma | No stoma | 0.972 | 0.433-2.180 | .945 |
| FACT-G total score | 1 | 0.986 | 0.970-1.001 | .075 |
| Physical well-being score | 1 | 0.966 | 0.925-1.008 | .110 |
| Social/Family well-being score | 1 | 0.976 | 0.936-1.018 | .258 |
| Emotional well-being score | 1 | 0.990 | 0.939-1.045 | .721 |
| Functional well-being score | 1 | 0.953 | 0.912-0.996 | .034 |
Abbreviations: HRQoL, health-related quality of life; HR, hazard ratio; ECOG, Eastern Cooperative Oncology Group; FACT-G, Functional Assessment Cancer Therapy–General.