Table 3.

Summary of outcome measures used in each included study – (indicated by √).

Study	Summary	MCA velocity	Cerebrovascular reactivity	pCO2	SPECT	Other
Al-Amran et al.44	N = 18 diabetics N = 17 controls	√	√ (TCD)
Arnavaz et al.37	N = 6	√
Chan et al.46	N = 10	√				√ regional O2 Saturation
Dhar et al.51	N = 6					√ PET imaging
Diomedi et al.38	N = 14 sildenafil N = 14 placebo	√	√ (TCD)	√
Jahshan et al.52	N = 14	√	√ (TCD)	√
Kruuse et al.39	N = 12	√			√
Kruuse et al.40	N = 12 (cross-over)	√		√	√
Kruuse et al.47	N = 13		√ (fMRI)	√
Lindberg et al.42	N = 12		√ (fMRI)	√		√ MRI (ASL, MRA and MCA dimension)
Lorberboym et al.48	N = 25				√
Lorberboym et al.43	N = 30				√
Mukherjee et al.49	N = 72	√
Rosengarten et al.45	N = 33	√	√ (TCD)	√		√ right heart catheterization
Van Osta et al.41	N = 35	√	√ (TCD)	√
Washington et al.50	N = 12					√ cerebral angiography
		N = 257	N = 170	N = 147	N = 79