Table 1.

Genotype and allele frequencies of the IL-1RA VNTR and IL-1β TaqI gene polymorphisms in COM patients and controls

Genotype	COM (n=189)	Control (n=119)	P-valuea)	Allele frequency
				Allele	COM	Control	P-valuea)
IL-1RA VNTR							<0.01
11	133 (70.4)	60 (50.4)		1	0.81	0.71
12	38 (20.1)	40 (33.6)		2	0.16	0.26	0.005
13	5 (2.7)	8 (6.7)	0.006	3	0.03	0.03
22	10 (5.3)	11 (9.3)
23	1 (0.5)	0
33	2 (1.0)	0
IL-1β TaqI
11	110 (58.2)	61 (51.3)		1	0.77	0.73	0.285
12	70 (37.1)	51 (42.8)	0.487	2	0.23	0.27
22	9 (4.7)	7 (5.9)

Values are presented as number (%).

IL-1RA, interleukin-1 receptor antagonist; VNTR, variable number tandem repeat; IL-1β, interleukin-1 beta; COM, chronic otitis media.

^a)P-value (chi-square) of the difference in genotype and allele frequency distribution.