Scheme 1. Substrate scope of imidazole C–H arylation with phenol derivatives. a Unless otherwise noted, the reaction conditions were as follows: 1 (0.40 mmol), 2 (1.5 equiv.), Ni(OTf)2 (10 mol%), dcype (12 mol%), K3PO4 (3.0 equiv.), t-amylOH (1.6 mL), 110 °C, and 12–36 h. b Ni(cod)2 (10 mol%) was used. c Ni(cod)2 (10 mol%) and dcypt (12 mol%) were used. d Starting from ethyl 4-imidazolecarboxylate 1P. (R = Et: 33%; t-amyl: 60%). e Starting from methyl 3-((dimethylcarbamoyl)oxy)benzoate (2f).
