Table 1. Screening of the reaction conditions ^a .

Entry	Ligand	Base	Solvent	3Aa b (%)
1	dcype	Cs2CO3	1,4-Dioxane	0
2	dcype	K3PO4	t-AmylOH	83
3	dcype	K3PO4	t-BuOH	70
4	dcype	K3PO4	1,4-Dioxane	0
5	dcype	K3PO4	DMF	0
6	dcype	K3PO4	i-PrOH	0
7	dcype	Cs2CO3	t-AmylOH	44
8	dcype	LiOt-Bu	t-AmylOH	59
9	dcype	KOt-Bu	t-AmylOH	0
10	PCy3	K3PO4	t-AmylOH	0
11	IPr·HCl	K3PO4	t-AmylOH	0
12	dcypt	K3PO4	t-AmylOH	55
13	L1	K3PO4	t-AmylOH	53
14	L2	K3PO4	t-AmylOH	64
15 c	dcype	K3PO4	t-AmylOH	82

^aUnless otherwise noted, the reaction conditions were as follows: 1A (0.40 mmol), 2a (1.5 equiv.), Ni(cod)₂ (10 mol%), ligand (bidentate: 12 mol%, monodentate: 24 mol%), base (3.0 equiv.), solvent (1.6 mL), 110 °C, and 12 h.

^bGC yield.

^cNi(OTf)₂ (10 mol%) was used.