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. 2018 May 7;9:834. doi: 10.3389/fimmu.2018.00834

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Copyright © 2018 Darlington, Stopnicki, Touil, Doucet, Fawaz, Roberts, Boivin, Arbour, Freedman, Atkins and Bar-Or.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in blood natural killer (NK) cell populations correlate with changes in helper T (Th) cells populations following aHSCT in MS patients. MS patient peripheral blood mononuclear cell (PBMC) samples from baseline (BL) and 12 month post-aHSCT were activated in vitro with anti-CD3, anti-CD28, and Th17 polarizing factors for 4 days. Th17 and Th1 cells were assessed by analysis of cytokine production by intracellular flow cytometry (CD3⁺CD4⁺IL-17A⁺IFN-γ⁻ or CD3⁺CD4⁺IL-17A⁻IFN-γ⁺, respectively). The change in frequency of Th17 cells (A) or Th1 cells (B) was plotted against the change in NK cell frequency, and linear regression was performed on the data points. N = 7 patients.