Table 2. AD targets and their best-associated plant with the most compounds docking with the target.
| Target | Top1 Plant | Target | Top1 Plant | Target | Top1 Plant |
|---|---|---|---|---|---|
| PLA2 | Bletilla(5)a | HMG-COA | Morus(9) | Caspase-3 | Paeonia(4) |
| MAOB | Corydalis(16) | PDE4 | Isatis(4) | Ftase | Panax(8) |
| QC | Panax(4) | TNF | Panax(10) | IDO | Morus(7) |
| Fyn | Papaver(11) | HDAC | Bletilla(5) | MAOA | Corydalis(11) |
| lyn | Claviceps(5) | JNK | Morus(8) | EGFR | Artemisia(7) |
| RARb | Rauwolfia(8) | RAGE | Fritillaria(7) | BACE-1 | Lonicera(6) |
| AchE | Piper(6) | SIRT1 | Panax(18) | GABA(B) | Morus(11) |
| RXR | Salvia(10) | MGLUR | Morus(4) | DYRK1A | Strychnos(6) |
| GLP-1R | Panax(9) | FGFR1 | Rheum(6) | α7NACHR | Panax(8) |
| AMPA | Panax(7) | SIG-1R | Corydalis(7) | CKI-δ | Salvia(11) |
Notes.
a
The numbers in this table are compound numbers which the best-associated plant for each target protein contains.
b
The docking energy of TCM compounds is higher than that of the original ligand for RAR protein.