Table 3.
Beta weights for prediction of age 16 outcome
| A | |
|---|---|
|
| |
| Predictors | Mean Betas |
| Demographic information | |
|
| |
| Age | 0.101 |
| Sex (male) | −0.079 |
| Site | 0.105 |
| Handedness (right-handed) | −0.182 |
| Symptoms | |
|
| |
| Psychotic-like experiences at baseline | 0.577 |
| Brain ROIs | |
|
| |
| dlPFC during failed inhibition | 0.021 |
| Caudate during failed inhibition | −0.088 |
| Cerebellum during angry faces processing | 0.276 |
| Hippocampus/amygdala during neutral faces processing | 0.253 |
| Middle temporal during neutral faces processing | 0.070 |
| Cerebellum during neutral faces processing | −0.234 |
| Inferior frontal during neutral faces processing | −0.126 |
| Lingual gyrus during neutral faces processing | −0.142 |
| Fusiform gyrus during neutral faces processing | −0.077 |
| ACC/MCC during anticipation of reward | 0.066 |
| Fusiform gyrus during anticipation of reward | −0.216 |
| B | |
|---|---|
|
| |
| Predictors | Mean Betas |
| Demographic and substance use information | |
|
| |
| Cannabis use in the previous year | 0.137 |
| Lifetime cigarette use | 0.150 |
| Symptoms | |
|
| |
| Internalizing behaviors | 0.307 |
| Externalizing behaviors | 0.084 |
| Brain ROIs | |
|
| |
| Cerebellum during angry faces processing | 0.092 |
| Hippocampus/amygdala during neutral faces processing | 0.073 |
| Cerebellum during neutral faces processing | −0.090 |
| C | |
|---|---|
|
| |
| Predictors | Mean Betas |
| Demographic and substance use information | |
|
| |
| Age | 0.027 |
| Sex (male) | 0.188 |
| Site | 0.023 |
| Handedness (right-handed) | −0.020 |
| Puberty development score | 0.077 |
| Cannabis use in the previous year | 0.250 |
| Lifetime cigarette use | 0.268 |
| Alcohol use in the previous year | −0.171 |
| Symptoms | |
|
| |
| Internalizing behaviors | 0.297 |
| Externalizing behaviors | 0.098 |
| Brain ROIs | |
|
| |
| dlPFC during failed inhibition | 0.100 |
| Caudate during failed inhibition | −0.142 |
| Cerebellum during angry faces processing | 0.317 |
| Hippocampus/amygdala during neutral faces processing | 0.192 |
| Middle temporal during neutral faces processing | 0.100 |
| Cerebellum during neutral faces processing | −0.066 |
| Inferior frontal during neutral faces processing | −0.101 |
| Lingual gyrus during neutral faces processing | −0.158 |
| Fusiform gyrus during neutral faces processing | −0.135 |
| ACC/MCC during anticipation of reward | −0.005 |
| Fusiform gyrus during anticipation of reward | −0.306 |
| D | |
|---|---|
|
| |
| Predictors | Mean Betas |
| Demographic information | |
|
| |
| Age | −0.024 |
| Sex (male) | −0.053 |
| Site | −0.097 |
| Handedness (right-handed) | 0.041 |
| Puberty development score | 0.096 |
| Cannabis use in the previous year | 0.140 |
| Lifetime cigarette use | −0.057 |
| Alcohol use in the previous year | 0.058 |
| Symptoms | |
|
| |
| Internalizing behaviors | 0.154 |
| Externalizing behaviors | 0.100 |
| Brain ROIs | |
|
| |
| Caudate during failed inhibition | 0.062 |
| Cerebellum during angry faces processing | −0.083 |
| Hippocampus/amygdala during neutral faces processing | −0.029 |
| Middle temporal during neutral faces processing | −0.025 |
| Cerebellum during neutral faces processing | −0.132 |
| Inferior frontal during neutral faces processing | 0.036 |
| Lingual gyrus during neutral faces processing | 0.071 |
| Fusiform gyrus during neutral faces processing | 0.039 |
| ACC/MCC during anticipation of reward | 0.025 |
| Fusiform gyrus during anticipation of reward | 0.088 |
Abbreviations: dlPFC, dorsolateral prefrontal cortex; ACC/MCC, anterior/middle cingulate cortex.
A, Mean beta weights (averaged over 10 outer folds) of the features that were present in at least 9 folds (out of 10) of the final model for classification of the mood and psychotic symptoms group versus the no mood symptoms group in the London-Dublin subsample. B, Mean beta weights (averaged over 10 outer folds) of the features that were present in at least 9 folds (out of 10) of the final model for classification of the mood and psychotic symptoms group versus the no mood symptoms group in the full IMAGEN sample. C, Mean beta weights (averaged over 10 outer folds) of the features that were present in at least 9 folds (out of 10) of the final model for classification of the mood and psychotic symptoms group versus the mood symptoms only group in the full IMAGEN sample. D, Mean beta weights (averaged over 10 outer folds) of the features that were present in at least 9 folds (out of 10) of the final model for classification of the mood symptoms only group versus the no mood symptoms group in the full IMAGEN sample.