Figure 1. Concentrations of maternal plasma angiogenic and anti-angiogenic factors in patients with fetal death.

For each fetal death case, data for one sample collected at 24–28 weeks are shown; triangles identify cases without placental lesions of maternal vascular underperfusion (MVU) and filled circles represent cases with MVU. The lines correspond with the percentiles of the analytes (or ratios) (2.5^th, 10^th, 50^th, 90^th, and 97.5^th centiles). The distribution of the raw longitudinal data used to derive the percentiles is shown using a heat map; the color intensity denotes the frequency of the data points for the corresponding gestational age: A) soluble vascular endothelial growth factor receptor-1, B) soluble endoglin, C) placental growth factor and D) placental growth factor/soluble endoglin ratio.