Table 2.
Typical substrates of basic CYP isozymes
| CYP isozyme | Substrates |
|---|---|
| CYP1A2 | Clozapine, caffeine, paracetamol, theophylline, phenacetin, R-warfarin |
| CYP2C9 | Hexobarbital, zidovudine, losartan, paracetamol, testosterone, tolbutamide, phenytoin, celecoxib, S-warfarin |
| CYP2C19 | Hexobarbital, diazepam, zidovudine, omeprazole, pantoprazole, testosterone, phenytoin, R-warfarin, S-warfarin |
| CYP2D6 | Haloperidol, dextromethorphan, codeine, metoprolol, nortriptyline, paracetamol, pravastatin, propafenone |
| CYP3A4 | Alprazolam, atorvastatin, vincristine, halothane, hydrocortisone, zidovudine, carbamazepine, codeine, cortisol, caffeine, lidocaine, lovastatin, midazolam, nifedipine, paracetamol, tacrolimus, tamoxifen, testosterone, phenytoin, cyclosporine, cyclophosphamide, erythromycin, R-warfarin, S-warfarin |