Figure 1.

CHE reduced cell viability in prostate cancer cells.

Notes: (A) The chemical structure of CHE. (B) The effects of CHE on cell viability in human prostate cancer cells. PC-3 cells or DU145 cells were treated with CHE at different concentration ranges as indicated for 24 or 48 h, then cell viability was determined by MTT assay, and the IC₅₀ values were indicated. (C) The effects of CHE treatment on colony formation. PC-3 cells or DU145 cells were treated for 24 h and stained with crystal violet on day 7. (D) The colony formation ability of each group is shown in bar chart. The statistic data were presented as mean ± SE from three independent experiments. *p<0.05, **p<0.01, ***p<0.001; ^#p<0.05, ^##p<0.01 and ^###p<0.001; all versus DMSO group.

Abbreviation: CHE, chelerythrine.