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. 2018 May 8;11:2673–2683. doi: 10.2147/OTT.S159913

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© 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited

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The expression of CIRP in tumors from different groups. Immunohistochemistry was conducted to determine the percentage of cold-inducible RNA-binding protein (CIRP)-positive cells in tumor xenografts. Scale bar, 50 μm. (A) Histological specimens show more CIRP⁺ cells in IT, than in IV, BEV-treated tumors. (B) Statistical analysis of the percentage of CIRP⁺ cells within the tumors. The final outcome was calculated as a ratio (CIRP⁺ cells/all cells in a field).

Notes: Data are represented as mean ± SD (n=10), **p<0.01.

Abbreviations: IT, intratumoral; IV, intravenousl; BEV, bevacizumab.