TABLE 2.
Occurrence of Hypoglycemia and Gastrointestinal Symptoms Comparing Propensity Score–Matched Cohorts of Injectable-Naive EQW (n = 2,008) and BI (n = 4,016) Initiators, 2012–2015
| Event | Group | Cohort | n | Number With at Least One Event (%) | Incidence per 1,000 Person-Years* (95% CI) | RR (95% CI) |
|---|---|---|---|---|---|---|
| Hypoglycemia | All | EQW | 2,008 | 149 (7.4) | 52.5 (44.4–61.6) | 0.80 (0.66–0.97) |
| BI | 4,016 | 368 (9.2) | 65.7 (59.1–72.7) | Reference | ||
| No prior hypoglycemia | EQW | 1,917 | 97 (5.1) | 34.9 (28.3–42.5) | 0.68 (0.54–0.86) | |
| BI | 3,841 | 279 (7.3) | 51.1 (45.3–57.5) | Reference | ||
| GI symptoms | Nausea | EQW | 2,008 | 301 (15.0) | 114.0 (101.5–127.7) | 1.17 (1.01–1.34) |
| BI | 4,016 | 532 (13.3) | 97.9 (89.7–106.5) | Reference | ||
| Vomiting | EQW | 2,008 | 194 (9.7) | 70.0 (60.5–80.6) | 1.13 (0.95–1.35) | |
| BI | 4,016 | 349 (8.7) | 61.8 (55.5–68.7) | Reference | ||
| Constipation | EQW | 2,008 | 149 (7.4) | 52.9 (44.7–62.1) | 1.00 (0.83–1.22) | |
| BI | 4,016 | 299 (7.5) | 52.6 (46.8–58.9) | Reference | ||
| Diarrhea | EQW | 2,008 | 263 (13.1) | 97.8 (86.3–110.3) | 1.15 (0.99–1.34) | |
| BI | 4,016 | 464 (11.6) | 84.7 (77.2–92.7) | Reference | ||
| Nausea and vomiting | EQW | 2,008 | 340 (16.9) | 130.9 (117.4–145.6) | 1.20 (1.05–1.37) | |
| BI | 4,016 | 590 (14.7) | 109.5 (100.8–118.7) | Reference | ||
| Diarrhea and constipation | EQW | 2,008 | 365 (18.2) | 142.0 (127.8–157.4) | 1.14 (1.00–1.30) | |
| BI | 4,016 | 656 (16.3) | 124.5 (115.2–134.5) | Reference | ||
| Any GI symptoms | EQW | 2,008 | 534 (26.6) | 225.5 (206.8–245.5) | 1.18 (1.06–1.31) | |
| BI | 4,016 | 946 (23.6) | 191.0 (179.1–203.6) | Reference |
*
Incidence rate per 1,000 person-years, with person-time censored at time of first event. GI, gastrointestinal.