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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Clin Cancer Res. 2017 Mar 27;23(15):4429–4440. doi: 10.1158/1078-0432.CCR-17-0162

Figure 2. Stromal and metabolic features are associated with prognosis.

Figure 2

(A) PDAC cases exhibit distinct stromal volume as shown in the representative images. PDAC were stratified based on stromal volume and the association with survival is shown. (B) PDAC cases exhibit three distinct stromal subtypes as shown in the representative images. Cases were stratified based on stromal type and the immature form of PDAC stroma was significantly associated with poor prognosis as determined by Kaplan-Meier analysis. (C) The expression of MCT4 and CA9 are markers of glycolytic and hypoxic environments respectively. The high expression of each marker was significantly associated with poor prognosis as determined by Kaplan-Meier analysis. (D) The stromal volume, stromal MCT4 expression, or stromal CA9 expression were evaluated dependent on the stromal type. Statistical association was determined by t-test (*p<0.05,**p<0.01,***p<0.001). (E) Multivariate analysis of the prognostic significance of stromal volume, stromal type, stromal MCT4, or stromal CA9 were determined against the clinical variable grade, tumor stage, and nodal status. Each marker remains significant in the multivariate model.