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. 2018 Apr 12;11(4):596. doi: 10.3390/ma11040596

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Schematic illustration of the procedure of tumor cells death after treated with FPO@HMSNs-PAA and soft-X-ray irradiation. In blood vessels, FPO@HMSNs-PAA accumulates around tumor tissues and enters into tumor cells via endocytosis. FPO released from FPO@HMSNs-PAA to produce H₂O₂ and O₂ in the tumor acidic microenvironment. Under soft-X-ray irradiation, reactive oxygen species (ROS) level enhances with the generation of ROS, which can cause damage to DNA and further lead to tumor cells death.