Table 3. The genotypes of five SNPs and serum lipid profiles (mmol/L) in normal and dyslipidemic individuals.
| SNPs | Group | Genotype | TG | TC | LDL-C | HDL-C |
|---|---|---|---|---|---|---|
| rs670 | control | AA | 0.95(0.86–1.09) * | 4.33(4.05–4.74) | 2.33(1.99–2.50) | 1.41(1.21–1.50) |
| AG | 0.79(0.61–0.98) * | 4.11(3.49–4.58) | 1.96(1.60–2.51) | 1.41(1.25–1.60) | ||
| GG | 0.77(0.59–0.95) * | 4.02(3.62–4.43) | 1.94(1.65–2.37) | 1.40(1.24–1.62) | ||
| case | AA | 2.02(1.57–2.89) | 4.68(3.54–5.86) | 2.42(1.68–3.58) | 0.92(0.88–0.98) | |
| AG | 2.18(1.13–2.80) | 4.96(3.75–6.24) | 2.66(1.87–3.36) | 0.95(0.82–1.17) | ||
| GG | 1.93(1.18–2.68) | 4.64(3.82–6.13) | 2.63(1.97–3.40) | 0.97(0.85–1.21) | ||
| rs1800976 | control | CC | 0.77(0.62–0.98) | 4.04(3.47–4.45) | 1.91(1.55–2.32) | 1.39(1.25–1.60) |
| CG | 0.78(0.61–0.97) | 4.11(3.65–4.54) | 2.00(1.70–2.46) | 1.42(1.25–1.64) | ||
| GG | 0.76(0.58–0.91) | 4.00(3.55–4.38) | 1.94(1.67–2.33) | 1.38(1.23–1.57) | ||
| case | CC | 1.76(1.09–2.50) | 4.91(3.70–6.26) | 2.67(1.93–3.42) | 0.9(0.86–1.20) | |
| CG | 2.17(1.25–2.78) | 4.73(3.85–6.13) | 2.63(2.00–3.48) | 0.96(0.83–1.22) | ||
| GG | 1.98(1.19–2.68) | 4.63(3.76–5.85) | 2.63(1.91–3.29) | 0.96(0.84–1.18) | ||
| rs4149313 | control | AA | 0.77(0.61–0.96) | 4.07(3.56–4.52) | 1.97(1.64–2.47) | 1.41(1.23–1.64) |
| AG | 0.78(0.59–0.96) | 4.08(3.62–4.48) | 1.95(1.68–2.35) | 1.39(1.25–1.58) | ||
| GG | 0.78(0.63–0.94) | 4.01(3.53–4.45) | 1.94(1.63–2.39) | 1.43(1.24–1.63) | ||
| case | AA | 2.10(1.34–2.77) | 4.64(3.78–5.93) | 2.54(2.01–3.38) | 0.96(0.84–1.19) | |
| AG | 1.91(1.13–2.69) | 4.70(3.84–6.22) | 2.70(1.94–3.36) | 0.97(0.83–1.21) | ||
| GG | 2.02(1.14–2.68) | 4.79(3.70–6.21) | 2.56(1.89–3.49) | 0.96(0.87–1.16) | ||
| rs2292318 | control | CC | 0.75(0.59–0.93) * | 4.03(3.58–4.47) | 1.93(1.64–2.37) | 1.43(1.25–1.63) |
| CT | 0.80(0.61–1.03) * | 4.14(3.60–4.51) | 2.02(1.67–2.46) | 1.36(1.23–1.56) | ||
| TT | 0.87(0.76–1.11) * | 4.08(3.77–4.60) | 2.01(1.81–2.18) | 1.34(1.21–1.55) | ||
| case | CC | 2.01(1.17–2.70) | 4.90(3.80–6.29) | 2.69(1.97–3.54) | 0.97(0.84–1.23) | |
| CT | 1.89(1.14–2.69) | 4.47(3.74–5.64) | 2.39(1.88–3.23) | 0.95(0.83–1.11) | ||
| TT | 2.45(1.18–3.04) | 4.37(4.10–5.46) | 2.53(2.00–3.34) | 1.01(0.89–1.14) | ||
| rs1109166 | control | AA | 0.76(0.60–0.94) | 4.03(3.58–4.48) | 1.92(1.65–2.36) | 1.43(1.24–1.63) |
| AG | 0.80(0.59–0.98) | 4.08(3.60–4.48) | 2.03(1.64–2.47) | 1.38(1.23–1.58) | ||
| GG | 0.84(0.62–1.12) | 4.15(3.79–4.61) | 1.89(1.67–2.17) | 1.32(1.24–1.55) | ||
| case | AA | 2.02(1.17–2.72) | 4.92(3.78–6.29) | 2.69(1.98–3.48) | 0.97(0.84–1.23) | |
| AG | 1.89(1.17–2.68) | 4.55(3.76–5.75) | 2.43(1.89–3.31) | 0.96(0.83–1.18) | ||
| GG | 2.02(1.18–3.04) | 4.32(4.02–5.21) | 2.35(2.00–3.07) | 0.95(0.77–1.03) |
TC: Total Cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein-cholesterol; LDL-C: low-density lipoprotein-cholesterol;
*P<0.025.
Lipid levels were presented with median and interquartile range (25th, 75th percentile). Kruskal Wallis test was used to obtained P value.