Table 1. Functionally annotated HPs from T. pallidum ssp. pallidum.
| S. No | Protein name | GeneID | Uniprot ID | Function |
|---|---|---|---|---|
| 1. | HP TPASS_0017 | 6333127 | B2S1W5 | Tetratricopeptide repeat containing protein |
| 2. | HP TPASS_0022 | 6333189 | B2S1X0 | Helicase C terminal domain protein |
| 3. | HP TPASS_0024 | 6333763 | B2S1X2 | Potassium ion(K+) transporter |
| 4. | HP TPASS_0025 | 6332893 | B2S1X3 | Peptidase M16(Metalloenzyme) |
| 5. | HP TPASS_0042 | 6333174 | B2S1Z0 | Peptidoglycan binding(LysM domain- bacterial cell wall degradation) |
| 6. | HP TPASS_0046 | 6332886 | B2S1Z4 | PSP1 C-terminal(polymerase suppressor 1) |
| 7. | HP TPASS_0048 | 6333172 | B2S1Z6 | Polymer forming cytoskeletal |
| 8. | HP TPASS_0049 | 6332885 | B2S1Z7 | Peptidoglycan hydrolase(Peptidase M23)(LytM domain) |
| 9. | HP TPASS_0050 | 6333168 | B2S1Z8 | Phosphoribosyl transferase(PRTase) |
| 10. | HP TPASS_0054 | 6333745 | B2S202 | RNA 2’-O ribose methyltransferase(Substrate binding) |
| 11. | HP TPASS_0055 | 6332884 | B2S203 | Oxaloacetate decarboxylase (gamma subunit) |
| 12. | HP TPASS_0064 | 6332880 | B2S212 | Alpha-ketoacid dehydrogenase kinase(N terminal) |
| 13. | HP TPASS_0065 | 6333159 | B2S213 | S-adenosyl-L-methionine-dependent methyltransferases |
| 14. | HP TPASS_0066 | 6333156 | B2S214 | Tetratricopeptide repeat containing protein |
| 15. | HP TPASS_0067 | 6332879 | B2S215 | Tetratricopeptide repeat containing protein |
| 16. | HP TPASS_0068 | 6333820 | B2S216 | Ribosomal RNA large subunit methyltransferase N (Radical SAM enzyme) |
| 17. | HP TPASS_0072 | 6333819 | B2S220 | Glutaredoxin |
| 18. | HP TPASS_0073 | 6333821 | B2S221 | Metal dependent phosphohydrolases with conserved 'HD' motif |
| 19. | HP TPASS_0079 | 6333203 | B2S227 | Xanthine dehydrogenase(Molibdoprotein binding) |
| 20. | HP TPASS_0081 | 6332890 | B2S229 | Xanthine dehydrogenase(Molibdoprotein binding, FAD binding) |
| 21. | HP TPASS_0083 | 6333811 | B2S231 | glycosyl hydrolase |
| 22. | HP TPASS_0084 | 6333817 | B2S232 | Thioredoxin |
| 23. | HP TPASS_0086 | 6333164 | B2S234 | PilZ domain containing protein(c-di-GMP binding) |
| 24. | HP TPASS_0095 | 6332871 | B2S243 | Tetratricopeptide repeat containing protein |
| 25. | HP TPASS_0121 | 6333137 | B2S269 | Lysine-2,3-aminomutase |
| 26. | HP TPASS_0123 | 6332867 | B2S271 | Tetratricopeptide repeat containing protein |
| 27. | HP TPASS_0126 | 6333787 | B2S274 | Outer membrane protein (beta-barrel domain) |
| 28. | HP TPASS_0139 | 6333134 | B2S287 | Potassium ion(K+) transporter(NAD(P) binding) |
| 29. | HP TPASS_0151 | 6332899 | B2S298 | NADH-quinone reductase(NQR2/RnfD) |
| 30. | HP TPASS_0153 | 6333195 | B2S2A0 | Acid phosphatase/vanadium-dependent haloperoxidase |
| 31. | HP TPASS_0154 | 6333194 | B2S2A1 | RNA pseudouridylate synthase |
| 32. | HP TPASS_0156 | 6333198 | B2S2A3 | 4-hydroxybenzoyl-CoA thioesterase |
| 33. | HP TPASS_0157 | 6333190 | B2S2A4 | Glycerol-3-phosphate O-acyltransferase |
| 34. | HP TPASS_0158 | 6333188 | B2S2A5 | Haloacid dehalogenase |
| 35. | HP TPASS_0181 | 6333597 | B2S2C8 | Septum formation initiator |
| 36. | HP TPASS_0182 | 6333036 | B2S2C9 | Telomere recombination(Sua5_yciO_yrdC family) |
| 37. | HP TPASS_0223 | 6333564 | B2S2H0 | Aspartate aminotransferase (EC 2.6.1.1)) |
| 38. | HP TPASS_0226 | 6333555 | B2S2H3 | Cobalt transport protein |
| 39. | HP TPASS_0231 | 6333017 | B2S2H8 | RNA pseudouridylate synthase |
| 40. | HP TPASS_0245 | 6333539 | B2S2J2 | P-loop containing nucleoside triphosphate hydrolases |
| 41. | HP TPASS_0246 | 6333538 | B2S2J3 | von Willebrand factor, type A(adhesive plasma glycoprotein) |
| 42. | HP TPASS_0253 | 6333526 | B2S2K1 | Polymer forming cytoskeletal |
| 43. | HP TPASS_0259 | 6333527 | B2S2K7 | Peptidoglycan binding(LysM domain- bacterial cell wall degradation) |
| 44. | HP TPASS_0260 | 6333524 | B2S2K8 | SH3-like domain, bacterial-type |
| 45. | HP TPASS_0263 | 6332801 | B2S2L1 | Fibronectin, type III |
| 46. | HP TPASS_0267 | 6333000 | B2S2L5 | Polymer forming cytoskeletal |
| 47. | HP TPASS_0268 | 6333517 | B2S2L6 | Tetratricopeptide repeat containing protein |
| 48. | HP TPASS_0269 | 6333513 | B2S2L7 | Methylthiotransferase, N-terminal(Radical SAM enzyme) |
| 49. | HP TPASS_0282 | 6332995 | B2S2N0 | Tetratricopeptide repeat containing protein |
| 50. | HP TPASS_0285 | 6333505 | B2S2N3 | Iron-Sulfer cluster binding protein(SPASM) |
| 51. | HP TPASS_0289 | 6332992 | B2S2N7 | S-adenosyl-L-methionine-dependent methyltransferases |
| 52. | HP TPASS_0290 | 6333501 | B2S2N8 | Haloacid dehalogenase |
| 53. | HP TPASS_0291 | 6333499 | B2S2N9 | FMN-dependent dehydrogenase |
| 54. | HP TPASS_0296 | 6333498 | B2S2P4 | Dephospho-CoA kinase |
| 55. | HP TPASS_0297 | 6333495 | B2S2P5 | sporulation and cell division repeat protein |
| 56. | HP TPASS_0301 | 6332987 | B2S2P9 | Branched chain Amino acid ABC transporter(Permease) |
| 57. | HP TPASS_0302 | 6333496 | B2S2Q0 | Branched chain Amino acid ABC transporter(Permease) |
| 58. | HP TPASS_0304 | 6333493 | B2S2Q2 | Peptidase MA |
| 59. | HP TPASS_0307 | 6332982 | B2S2Q5 | PASTA domain containing protein(penicillin binding- serine/threonine kinase) |
| 60. | HP TPASS_0310 | 6332983 | B2S2Q8 | single-stranded DNA-binding protein |
| 61. | HP TPASS_0333 | 6333459 | B2S2T0 | outer membrane lipoprotein carrier protein (LolA) |
| 62. | HP TPASS_0334 | 6332972 | B2S2T1 | DNA-binding helix-turn-helix protein(transcriptional regulator) |
| 63. | HP TPASS_0335 | 6333460 | B2S2T2 | CAAX amino terminal protease(Self Immunity) |
| 64. | HP TPASS_0339 | 6333457 | B2S2T6 | RNA pseudouridylate synthase |
| 65. | HP TPASS_0348 | 6332968 | B2S2U5 | Heptaprenyl diphosphate synthase |
| 66. | HP TPASS_0352 | 6332965 | B2S2U9 | Transcriptional Coactivator p15 |
| 67. | HP TPASS_0358 | 6333387 | B2S2V5 | Glycosyl hydrolase |
| 68. | HP TPASS_0369 | 6332954 | B2S2W6 | Tetratricopeptide repeat containing protein |
| 69. | HP TPASS_0371 | 6333425 | B2S2W8 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase |
| 70. | HP TPASS_0373 | 6332951 | B2S2X0 | tRNA(Ile)-lysidine synthase |
| 71. | HP TPASS_0374 | 6333405 | B2S2X1 | Tetratricopeptide repeat containing protein |
| 72. | HP TPASS_0381 | 6333396 | B2S2X8 | Integral membrane protein |
| 73. | HP TPASS_0384 | 6333390 | B2S2Y1 | S-adenosyl-L-methionine-dependent methyltransferases |
| 74. | HP TPASS_0385 | 6332927 | B2S2Y2 | Cell division protein FtsL (Septum formation initiator) |
| 75. | HP TPASS_0392 | 6333379 | B2S2Y9 | Tetratricopeptide repeat containing protein |
| 76. | HP TPASS_0404 | 6333523 | B2S301 | Metallo-beta-lactamase |
| 77. | HP TPASS_0412 | 6332827 | B2S309 | PUR-alpha/beta/gamma DNA/RNA-binding protein |
| 78. | HP TPASS_0421 | 6333062 | B2S318 | Tetratricopeptide repeat containing protein |
| 79. | HP TPASS_0423 | 6333060 | B2S320 | P-loop containing nucleoside triphosphate hydrolases |
| 80. | HP TPASS_0431 | 6333579 | B2S328 | Pantothenate kinase, type III |
| 81. | HP TPASS_0436 | 6333546 | B2S332 | Phosphoesterase(DHH family) |
| 82. | HP TPASS_0438 | 6333091 | B2S334 | Non-canonical purine NTP pyrophosphatase |
| 83. | HP TPASS_0441 | 6333698 | B2S337 | Inorganic polyphosphate/ATP-NAD kinase |
| 84. | HP TPASS_0444 | 6333752 | B2S340 | Peptidoglycan binding(LysM domain),peptidase M23 |
| 85. | HP TPASS_0447 | 6333695 | B2S343 | Tetratricopeptide repeat containing protein |
| 86. | HP TPASS_0449 | 6333086 | B2S345 | Tetratricopeptide repeat containing protein |
| 87. | HP TPASS_0458 | 6333084 | B2S354 | Chromosome segregation and condensation protein |
| 88. | HP TPASS_0459 | 6333689 | B2S355 | RNA pseudouridylate synthase |
| 89. | HP TPASS_0460 | 6333688 | B2S356 | Tetratricopeptide repeat containing protein |
| 90. | HP TPASS_0461 | 6333083 | B2S357 | DNA-binding helix-turn-helix protein(transcriptional regulator) |
| 91. | HP TPASS_0464 | 6333686 | B2S360 | tRNA (guanine-N(7)-)-methyltransferase |
| 92. | HP TPASS_0468 | 6333027 | B2S364 | Tetratricopeptide repeat containing protein |
| 93. | HP TPASS_0470 | 6333673 | B2S365 | Tetratricopeptide repeat containing protein |
| 94. | HP TPASS_0471 | 6333682 | B2S366 | Tetratricopeptide repeat containing protein |
| 95. | HP TPASS_0474 | 6333683 | B2S369 | DNA-binding regulatory protein(Trasncriptional regulator) |
| 96. | HP TPASS_0484 | 6333678 | B2S379 | FecR protein(regulation of iron dicitrate transport) |
| 97. | HP TPASS_0487 | 6333676 | B2S382 | Quinoprotein alcohol dehydrogenase |
| 98. | HP TPASS_0489 | 6333074 | B2S384 | Metallo-beta-lactamase |
| 99. | HP TPASS_0494 | 6332850 | B2S389 | Zinc ribbon domain containing protein |
| 100. | HP TPASS_0496 | 6333713 | B2S390 | Tetratricopeptide repeat containing protein |
| 101. | HP TPASS_0502 | 6333709 | B2S396 | Ankyrin repeat protein(protein binding) |
| 102. | HP TPASS_0512 | 6333669 | B2S3A6 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase |
| 103. | HP TPASS_0515 | 6333671 | B2S3A9 | Organic solvent tolerance protein |
| 104. | HP TPASS_0518 | 6333730 | B2S3B2 | Thiamin pyrophosphokinase |
| 105. | HP TPASS_0522 | 6332853 | B2S3B5 | Colicin V production protein |
| 106. | HP TPASS_0534 | 6333737 | B2S3C6 | V-type ATP synthase (subunit C) |
| 107. | HP TPASS_0544 | 6332856 | B2S3D6 | Endonuclease/Exonuclease/phosphatase |
| 108. | HP TPASS_0548 | 6333092 | B2S3E0 | Tetratricopeptide repeat containing protein |
| 109. | HP TPASS_0558 | 6333675 | B2S3F0 | Nickel/cobalt transporter, high-affinity |
| 110. | HP TPASS_0561 | 6332860 | B2S3F3 | TPM family (TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase) |
| 111. | HP TPASS_0563 | 6333116 | B2S3F5 | DnaJ domain-containing protein(molecular chaperon) |
| 112. | HP TPASS_0565 | 6333702 | B2S3F7 | SGNH hydrolase |
| 113. | HP TPASS_0567 | 6333260 | B2S3F9 | MgtE N-terminal domain containing protein(flagellar protein) |
| 114. | HP TPASS_0570 | 6333861 | B2S3G2 | TPM family (TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase) |
| 115. | HP TPASS_0572 | 6332874 | B2S3G4 | FMN-binding domain (Ferric reductase) |
| 116. | HP TPASS_0580 | 6333280 | B2S3H1 | Permease FtsX-like |
| 117. | HP TPASS_0582 | 6333797 | B2S3H3 | Permease FtsX-like |
| 118. | HP TPASS_0588 | 6333269 | B2S3H9 | DNA-directed DNA polymerase III delta subunit |
| 119. | HP TPASS_0592 | 6332921 | B2S3I3 | D-alanyl-D-alanine carboxypeptidase |
| 120. | HP TPASS_0599 | 6333138 | B2S3I9 | Zinc finger domain containing protein(DNA binding) |
| 121. | HP TPASS_0608 | 6333867 | B2S3J8 | ARM repeat containing protein(intracellular signalling and cytoskeletal regulation) |
| 122. | HP TPASS_0612 | 6333155 | B2S3K2 | Fe-S cluster assembly protein SufB |
| 123. | HP TPASS_0613 | 6333336 | B2S3K3 | Fe-S cluster assembly protein SufB |
| 124. | HP TPASS_0622 | 6332909 | B2S3L2 | Tetratricopeptide repeat containing protein |
| 125. | HP TPASS_0624 | 6332843 | B2S3L4 | Outer membrane protein, OmpA |
| 126. | HP TPASS_0625 | 6333262 | B2S3L5 | Tetratricopeptide repeat containing protein |
| 127. | HP TPASS_0636 | 6332923 | B2S3M5 | DNA repair protein RecO(Recombination) |
| 128. | HP TPASS_0648 | 6333773 | B2S3N7 | Tetratricopeptide repeat containing protein |
| 129. | HP TPASS_0651 | 6333776 | B2S3P0 | Metal-dependent phosphohydrolase, (7TM intracellular domain) |
| 130. | HP TPASS_0674 | 6332788 | B2S3R3 | Smr domain containing protein(DNA mismatch repair) |
| 131. | HP TPASS_0675 | 6333351 | B2S3R4 | Pheromone shutdown, TraB |
| 132. | HP TPASS_0691 | 6332917 | B2S3T0 | Prokaryotic chromosome segregation/condensation protein ScpA |
| 133. | HP TPASS_0699 | 6333718 | B2S3T8 | Transcriptional regulator, MerR family |
| 134. | HP TPASS_0702 | 6333746 | B2S3U1 | Peptidase M23 |
| 135. | HP TPASS_0706 | 6333365 | B2S3U5 | Peptidase M23 |
| 136. | HP TPASS_0710 | 6333662 | B2S3U9 | Jag_N family protein |
| 137. | HP TPASS_0719 | 6333069 | B2S3V8 | Flagellar biosynthesis protein, FliO |
| 138. | HP TPASS_0730 | 6333796 | B2S3W9 | CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase |
| 139. | HP TPASS_0731 | 6333510 | B2S3X0 | NUDIX hydrolase |
| 140. | HP TPASS_0733 | 6333500 | B2S3X2 | Outer membrane protein (beta-barrel domain) |
| 141. | HP TPASS_0738 | 6333488 | B2S3X7 | Iojap/ribosomal silencing factor |
| 142. | HP TPASS_0739 | 6333471 | B2S3X8 | Cell envelope-related transcriptional attenuator |
| 143. | HP TPASS_0740 | 6333287 | B2S3X9 | Metal dependent phosphohydrolases with conserved 'HD' moti |
| 144. | HP TPASS_0741 | 6332971 | B2S3Y0 | nicotinate-nucleotide adenylyltransferase |
| 145. | HP TPASS_0750 | 6333824 | B2S3Y9 | von Willebrand factor, type A(adhesive plasma glycoprotein) |
| 146. | HP TPASS_0752 | 6333218 | B2S3Z1 | Sporulation and Cell division repeat protein |
| 147. | HP TPASS_0764 | 6333596 | B2S403 | Metal dependent phosphohydrolases with conserved 'HD' motif |
| 148. | HP TPASS_0771 | 6333854 | B2S410 | Sodium-dependent phosphate transport protein |
| 149. | HP TPASS_0776 | 6333834 | B2S415 | Phosphoribosyltransferases |
| 150. | HP TPASS_0777 | 6333848 | B2S416 | Zinc finger protein(DNA binding) |
| 151. | HP TPASS_0782 | 6333666 | B2S421 | Peptidase M23 |
| 152. | HP TPASS_0784 | 6333829 | B2S423 | Lipopolysaccharide assembly, LptC |
| 153. | HP TPASS_0785 | 6332804 | B2S424 | Organic solvent tolerance(N terminal) |
| 154. | HP TPASS_0796 | 6333271 | B2S435 | Thiamine biosynthesis lipoprotein ApbE |
| 155. | HP TPASS_0803 | 6333380 | B2S442 | Phosphoesterase(DHH family) |
| 156. | HP TPASS_0815 | 6333371 | B2S453 | Acyl-CoA N-acyltransferase |
| 157. | HP TPASS_0820 | 6332940 | B2S458 | Tetratricopeptide repeat containing protein |
| 158. | HP TPASS_0822 | 6332941 | B2S460 | Mechanosensitive ion channel |
| 159. | HP TPASS_0826 | 6332943 | B2S464 | DisA bacterial checkpoint controller nucleotide-binding |
| 160. | HP TPASS_0832 | 6333406 | B2S470 | Sporulation and spore germination |
| 161. | HP TPASS_0840 | 6333412 | B2S478 | Major facilitator superfamily domain, general substrate transporter |
| 162. | HP TPASS_0846 | 6333419 | B2S484 | Cell division protein ZapA |
| 163. | HP TPASS_0851 | 6333426 | B2S489 | UDP-3-O-acylglucosamine N-acyltransferase |
| 164. | HP TPASS_0854 | 6333428 | B2S492 | HAMP domain-containing protein(regulation of phosphorylation or methylation of homodimeric receptors) |
| 165. | HP TPASS_0860 | 6332961 | B2S498 | Tetratricopeptide repeat containing protein |
| 166. | HP TPASS_0864 | 6332962 | B2S4A2 | Peptidase family M23 (LysM domain) |
| 167. | HP TPASS_0875 | 6333650 | B2S4B2 | ATP-binding protein |
| 168. | HP TPASS_0876 | 6333657 | B2S4B3 | Glycoprotease |
| 169. | HP TPASS_0877 | 6333357 | B2S4B4 | Metal dependent phosphohydrolases with conserved 'HD' motif |
| 170. | HP TPASS_0879 | 6333063 | B2S4B6 | ABC transporter |
| 171. | HP TPASS_0882 | 6332835 | B2S4B9 | ARM repeat containing protein(intracellular signalling and cytoskeletal regulation) |
| 172. | HP TPASS_0883 | 6333652 | B2S4C0 | Permease YjgP/YjgQ |
| 173. | HP TPASS_0884 | 6333655 | B2S4C1 | Permease YjgP/YjgQ |
| 174. | HP TPASS_0893 | 6333646 | B2S4D0 | Ribosome maturation factor RimP |
| 175. | HP TPASS_0894 | 6333059 | B2S4D1 | NYN domain, limkain-b1-type |
| 176. | HP TPASS_0899 | 6333640 | B2S4D6 | PD-(D/E)XK nuclease |
| 177. | HP TPASS_0900 | 6333058 | B2S4D7 | PD-(D/E)XK nuclease |
| 178. | HP TPASS_0901 | 6333638 | B2S4D8 | Multi antimicrobial extrusion protein |
| 179. | HP TPASS_0906 | 6333635 | B2S4E3 | KH domain containing protein (RNA binding) |
| 180. | HP TPASS_0907 | 6333636 | B2S4E4 | Ribosome maturation factor RimM |
| 181. | HP TPASS_0911 | 6333054 | B2S4E8 | Flagellar biosynthetic protein flhb |
| 182. | HP TPASS_0912 | 6333634 | B2S4E9 | Metal dependent phosphohydrolases with conserved 'HD' motif |
| 183. | HP TPASS_0913 | 6332830 | B2S4F0 | Restriction endonuclease, type II |
| 184. | HP TPASS_0915 | 6333052 | B2S4F2 | Tetratricopeptide repeat containing protein |
| 185. | HP TPASS_0920 | 6333051 | B2S4F7 | Tetratricopeptide repeat containing protein |
| 186. | HP TPASS_0923 | 6333048 | B2S4G0 | PEGA domain-containing protein |
| 187. | HP TPASS_0931 | 6333617 | B2S4G8 | Alpha-alpha trehalase |
| 188. | HP TPASS_0937 | 6333609 | B2S4H4 | Calcineurin-like phosphoesterase |
| 189. | HP TPASS_0942 | 6333611 | B2S4H9 | flagellar protein(FlgN) |
| 190. | HP TPASS_0944 | 6333040 | B2S4I1 | Tetratricopeptide repeat containing protein |
| 191. | HP TPASS_0954 | 6332869 | B2S4J1 | Tetratricopeptide repeat containing protein |
| 192. | HP TPASS_0959 | 6332970 | B2S4J6 | Rod binding protein(flagellar protein) |
| 193. | HP TPASS_0962 | 6333182 | B2S4J9 | Permease FtsX-like(efflux ABC transporter) |
| 194. | HP TPASS_0963 | 6333217 | B2S4K0 | Macrolide export ATP-binding/permease protein |
| 195. | HP TPASS_0972 | 6333285 | B2S4K9 | Macrolide export ATP-binding/permease protein |
| 196. | HP TPASS_0975 | 6333284 | B2S4L2 | rRNA small subunit methyltransferase I |
| 197. | HP TPASS_0977 | 6333282 | B2S4L4 | NIF3 (NGG1p interacting factor 3) |
| 198. | HP TPASS_0979 | 6332912 | B2S4L6 | TatD related DNase |
| 199. | HP TPASS_0986 | 6333008 | B2S4M3 | Multidrug resistance efflux transporter EmrE |
| 200. | HP TPASS_0988 | 6333049 | B2S4M5 | Multiple antibiotic resistance (MarC)-related |
| 201. | HP TPASS_0990 | 6333035 | B2S4M7 | Tetratricopeptide repeat containing protein |
| 202. | HP TPASS_0994 | 6333256 | B2S4N1 | TatD related DNase |
| 203. | HP TPASS_1018 | 6333868 | B2S4Q5 | 2',3'-cyclic-nucleotide 2'-phosphodiesterase |
| 204. | HP TPASS_1029 | 6333264 | B2S4R6 | RNA binding protein |
| 205. | HP TPASS_1032 | 6333263 | B2S4R9 | Transcription antitermination protein nusG |
| 206. | HP TPASS_1033 | 6333866 | B2S4S0 | Patatin-like phospholipase |
| 207. | HP TPASS_1034 | 6333278 | B2S4S1 | Sodium/calcium exchanger protein |