Table 2.

Common variants significantly associated with PR interval from meta-analysis of all studies

SNP	Locus	Closest gene	Function	Coding allele	CAF*	Beta	SE	P value	Number of studies‡	Prolong or shorten PR interval	Novel locus
rs6795970	3p22.2	SCN10A	Missense	A	0.37	0.1705	0.0052	4.0×10−240	27	Prolong
rs3922844	3p22.2	SCN5A	Intronic	A	0.34	−0.1069	0.0053	9.3×10−90	26	Shorten
rs3807989	7q31.2	CAV1	Intronic	A	0.43	0.0908	0.0050	3.0×10−74	27	Prolong
rs7660702	4q21.23	ARHGAP24	Intronic	C	0.33	−0.0921	0.0053	1.2×10−68	27	Shorten
rs17287293	12p12.1	LINC00477	Intergenic	G	0.14	−0.1084	0.0071	1.9×10−52	27	Shorten
rs11897119	2p14	MEIS1	Intronic	C	0.39	0.0566	0.0055	4.2×10−25	25	Prolong
rs1896312	12q24.21	TBX3	Intergenic	G	0.28	0.0564	0.0055	8.7×10−25	26	Prolong
rs883079	12q24.21	TBX5	3′UTR	G	0.29	0.0550	0.0054	4.5×10−24	26	Prolong
rs116202356	3p22.2	DLEC1	Missense	A	0.02	−0.1953	0.0199	1.0×10−22	27	Shorten
rs251253	5q35.1	CREBRF	Intergenic	G	0.42	−0.0439	0.0051	4.7×10−18	26	Shorten
rs11153730	6q22.31	SLC35F1	Intergenic	C	0.47	−0.0420	0.0049	9.5×10−18	27	Shorten	Novel
rs35658696	5q21.1	PAM	Missense	G	0.04	0.0956	0.0119	8.5×10−16	27	Prolong
rs2070492	3p22.2	SLC22A14	Missense	T	0.10	0.0624	0.0083	4.0×10−14	27	Prolong	Novel
rs2585897	13q12.11	XPO4	Intronic	A	0.17	0.0471	0.0064	2.8×10−13	27	Prolong
rs2042995	2q31.2	TTN	Missense	C	0.26	0.0375	0.0057	4.3×10−11	27	Prolong
rs4399693	2p25.1	ID2	Intergenic	A	0.34	0.0374	0.0058	9.1×10−11	25	Prolong
rs41306688	13q34	ADPRHL1	Missense	C	0.03	0.1002	0.0173	7.4×10−9	22	Prolong	Novel
rs4745	1q22	EFNA1	Missense	T	0.49	0.0299	0.0053	1.2×10−8	26	Prolong
rs11078078	17p12	LINC00670	Intronic	A	0.40	0.0281	0.0050	2.2×10−8	27	Prolong
rs60632610	10q22.2	SYNPO2L	Missense	T	0.15	−0.0371	0.0068	4.5×10−8	27	Shorten	Novel
rs11848785	14q24.2	SIPA1L1	Intronic	G	0.24	0.0317	0.0058	4.6×10−8	27	Prolong
rs3733414	4q35.2	FAT1	Missense	A	0.38	0.0280	0.0051	4.8×10−8	27	Prolong
rs17362588	2q31.2	CCDC141	Missense	A	0.08	−0.0491	0.0090	5.5×10−8	27	Shorten	Novel
rs2296172	1p34.3	MACF1	Missense	G	0.20	0.0326	0.0061	1.1×10−7	27	Prolong	Novel
rs9398652	6q22.31	GJA1	Intergenic	A	0.14	0.0390	0.0074	1.3×10−7	26	Prolong	Novel
rs442177	4q22.1	AFF1	Intronic	C	0.42	−0.0262	0.0050	1.8×10−7	26	Shorten	Novel
rs7002002	8q24.3	PLEC	Missense	A	0.38	−0.0272	0.0052	2.1×10−7	25	Shorten	Novel
rs1768208	3p22.1	MOBP	Intron	T	0.25	0.0288	0.0057	3.6×10−7	27	Prolong	Novel
rs2119788	4q34.1	HAND2	Intergenic	C	0.52	−0.0246	0.0049	5.6×10−7	27	Shorten	Novel
rs17391905†	1p32.3	C1orf185	Intergenic	G	0.03	−0.0694	0.0142	9.6×10−7	27	Shorten
rs524295	10q24.1	ALDH18A1	Intergenic	A	0.40	−0.0261	0.0053	9.7×10−7	26	Shorten

^*Coding allele frequency

^†SNP was not significant if African participants were excluded.

^‡Some variants did not reach pass the quality filtering in respective studies and thus were excluded.