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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Brain Struct Funct. 2017 Aug 3;223(1):233–253. doi: 10.1007/s00429-017-1487-y

Figure 10. RGS14 is localized pre-synaptically in the monkey substantia nigra pars reticulata.

Figure 10

(A) Light micrograph showing dense RGS14 neuropil labeling in the pars reticulata (SNr) of the monkey substantia nigra, while the pars compacta (SNc) is completely devoid of immunoreactivity. As in GPe and GPi, the SNr labeling is made up of rich plexuses of varicosities that display a woolly fibers-like pattern of innervation of dendritic processes. (B–C) At the electron microscope level, the immunostaining is mainly confined to pre-synaptic terminals (Ter) that display the ultrastructural features of striatonigral GABAergic boutons and form symmetric axo-dendritic synapses (blue arrowhead in C). (D) illustrates a subset of RGS14-immunoreactive terminals that forms asymmetric axo-dendritic synapses (red arrowheads). The amygdala is a potential source of these putative excitatory terminals.