Figure 3. Comparison of the VSL domain of selected TRP family members with the voltage-sensing domain of the chimeric KV1.2-KV2.1 channel.
(a) The voltage-sensing domain of the chimeric KV1.2-KV2.1 channel and the VSL domains of TRPC4DR,TRPP1, TRPM4, TRPM8 and TRPV1 are shown in ribbon representation. The S4 helix in each case is highlighted with dark shaded color. The rest of the domains are shown in light transparent color. The residues which form the hydrophobic patch in the middle of the domain are shown in golden yellow sphere representation with light transparency. The residues involved in ion-pair interactions are shown in stick representation. (b) The structures in (a) are rotated to better view the residues important for voltage sensing in the S4 helix of the chimeric KV1.2-KV2.1 channel and topological equivalent residues of TRP channels are shown in stick representation and labeled.