Table 2. Comparison of selectivity filters among TRP family members.
| TRP family name | Residue | Van der waals diameter (Å) | Selectivity* PCa: PNa |
Reference |
|---|---|---|---|---|
| TRPC4DR | G577 | 3.7 | 7 | |
| TRPV1 | G643 | 1.5 | 3.8–9.6 | (Liao et al., 2013) |
| TRPV2 | Gly604 (M606) |
1.9 (1.35) |
3 | (Zubcevic et al., 2016) |
| TRPML3 | G457 (D459) |
2.0 (4.2) |
Highly selective for Ca2+ | (Zhou et al., 2017) |
| TRPML1 | G470 (D471) | 1.4 (2.1) |
N.D. | (Schmiege et al., 2017) |
| TRPN (NOMPC) | G1506 | 3.8 | N.D. | (Jin et al., 2017) |
| TRPA1 | D915 | 3.2 | 0.8 | (Paulsen et al., 2015) |
| TRPV5 | D542 | 2.6 | >100 | (Hughes et al., 2018) |
| TRPV6 | D541 | 0.9 | >100 | (Saotome et al., 2016) |
| TRPM4 | G972 | 4.3 | PNa: PCa > 100 | (Guo et al., 2017a) |
| TRPP1 (PKD2) | Leu641 (Gly642) |
1.7 (3.6) |
PNa: PCa > 100 | (Shen et al., 2016a) |