Figure 2.

Location of Functional Domains and Post-Translational Modifications (PTMs) in Activating Transcription Factor 4 (ATF4). Residue numbers refer to the human amino acid sequence (UniProtKB entry P18848). ATF4 domain structure was adapted from [112]. PTMs were mapped using information from the PhosphoSite database [57] or literature as indicated in Table 1. Colors indicate the effect of the modification: black, activating; red, inactivating/destabilizing; grey, unknown.