Table 2.

Histone Modifications Required for ATF4 Target Gene Expression

Modification	Enzyme	Model	Target gene specificity	Ref.
H4 acetylation	Unknown	Histidine deprivation in MEFs	Required for Jmjd3, Chop, and Atf3, but not for Asns and Cat1	[78]
H3 acetylation	Unknown	Histidine deprivation or ER stress (thapsigargin) in human HepG2 cells	Required for SNAT2, but not for ASNS	[79]
H2B and H4 acetylation	p-ATF2	Amino acid deprivation in MEFs	Required for Chop and Atf3, but not for Asns	[80]
H3K9 demethylation	KDM4C	Serine deprivation in the human cancer cell lines HeLa and BE2C (neuroblastoma)	Required for the expression of most amino acid responsive genes	[81]