Table 2.

Family analyses: Risk of any AD in relatives of probands with OCD (top half of the table) and relatives of probands with TD/CTD (bottom half of the table).

	AD in relatives of OCD- probands	Relatives of OCD probands	AD in relatives of non-OCD probands	Relatives of non-OCD probands	OR (95% CI)	p-value
Siblings	2,709	40,356	693,544	10,630,103	1.16 (1.12-1.21)	<0.01
Mothers	3,404	29,492	767,675	7,387,101	1.17 (1.13-1.21)	<0.01
Fathers	2,381	29,492	541,109	7,387,101	1.08 (1.04-1.13)	<0.01
Maternal halfsiblings	548	8,617	89,075	1,412,006	1.08(0.98-1.18)	0.11
Paternal halfsiblings	603	10,531	115,433	1,831,206	0.99 (0.91-1.07)	0.76
Cousins	7,469	134,159	1,398,239	25,721,943	1.02(1.00-1.05)	0.07
	AD in relatives of TD/CTD probands	Relatives of TD/CTD probands	AD in relatives of non-TD/CTD probands	Relatives of Non-TD/CTD probands	OR (95 % CI)	p-value
Siblings	448	8,352	695,805	10,662,107	1.17 (1.06-1.31)	<0.01
Mothers	794	7,083	770,285	7,409,510	1.40 (1.30-1.51)	<0.01
Fathers	566	7,083	542,924	7,409,510	1.31 (1.20-1.42)	<0.01
Maternal halfsiblings	146	2,730	89,477	1,417,893	1.11 (0.93-1.33)	0.23
Paternal halfsiblings	169	3,090	115,883	1,838,647	1.09 (0.93-1.28)	0.29
Cousins	1,624	31,737	1,404,084	25,824,365	1.05 (1.00-1.11)	0.06

Footnotes: Statistically significant findings are marked in bold.

Abbreviations: AD = autoimmune diseases; CI = confidence interval; CTD = chronic tics disorder; OCD = obsessive-compulsive disorder; OR = odds ratio; TD = Tourette's disorder.