Table 3.
Frequently mutated genes in adenomas (AD)
| Gene | N a (%) | AD mutated samples;total mutations | Missense | Nonsense | INDEL/frameshift | CA mutated sample; N 2 (%) | ||
|---|---|---|---|---|---|---|---|---|
| (N = 17) | (N = 16) | |||||||
| APC | 12 | 70.59 | 22 | 1 | 13 | 8 | 14 | 87.50 |
| TTN | 7 | 41.18 | 12 | 7 | 0 | 5 | 8 | 50.00 |
| TP53 | 5 | 29.41 | 6 | 6 | 0 | 0 | 7 | 43.75 |
| KRAS | 5 | 29.41 | 5 | 4 | 0 | 1 | 7 | 43.75 |
| AMER1 | 4 | 23.53 | 5 | 0 | 5 | 0 | 1 | 6.25 |
| HYDIN | 4 | 23.53 | 5 | 5 | 0 | 0 | 0 | 0.00 |
| LRP1B | 4 | 23.53 | 4 | 3 | 1 | 0 | 1 | 6.25 |
| RYR2 | 4 | 23.53 | 4 | 2 | 1 | 1 | 1 | 6.25 |
| MGAT4B | 4 | 23.53 | 4 | 3 | 0 | 1 | 0 | 0.00 |
| SLIT3 | 4 | 23.53 | 4 | 3 | 0 | 1 | 0 | 0.00 |
| DMXL2 | 3 | 17.65 | 4 | 3 | 0 | 1 | 0 | 0.00 |
| ZNF536 | 3 | 17.65 | 4 | 3 | 0 | 1 | 0 | 0.00 |
| OBSCN | 3 | 17.65 | 3 | 2 | 0 | 1 | 7 | 43.75 |
| SOX9 | 3 | 17.65 | 3 | 0 | 1 | 2 | 3 | 18.75 |
| PCDH17 | 3 | 17.65 | 3 | 2 | 0 | 1 | 2 | 12.50 |
| SIGLEC10 | 3 | 17.65 | 3 | 3 | 0 | 0 | 2 | 12.50 |
| ARMCX4 | 3 | 17.65 | 3 | 2 | 0 | 1 | 1 | 6.25 |
| GOLGB1 | 3 | 17.65 | 3 | 2 | 0 | 1 | 1 | 6.25 |
| NAV3 | 3 | 17.65 | 3 | 3 | 0 | 0 | 1 | 6.25 |
| PHACTR1 | 3 | 17.65 | 3 | 3 | 0 | 0 | 1 | 6.25 |
| ANKLE1 | 3 | 17.65 | 3 | 2 | 0 | 1 | 0 | 0.00 |
| CACNA1A | 3 | 17.65 | 3 | 1 | 1 | 1 | 0 | 0.00 |
| CSMD2 | 3 | 17.65 | 3 | 2 | 0 | 1 | 0 | 0.00 |
| DOCK4 | 3 | 17.65 | 3 | 2 | 0 | 1 | 0 | 0.00 |
| FAM9A | 3 | 17.65 | 3 | 2 | 0 | 1 | 0 | 0.00 |
| HERC2 | 3 | 17.65 | 3 | 2 | 0 | 1 | 0 | 0.00 |
| KCNT1 | 3 | 17.65 | 3 | 3 | 0 | 0 | 0 | 0.00 |
| KIAA1109 | 3 | 17.65 | 3 | 2 | 0 | 1 | 0 | 0.00 |
| MUC3A | 3 | 17.65 | 3 | 1 | 0 | 2 | 0 | 0.00 |
| NACAD | 3 | 17.65 | 3 | 0 | 0 | 3 | 0 | 0.00 |
| RASGRF1 | 3 | 17.65 | 3 | 3 | 0 | 0 | 0 | 0.00 |
| ZNF835 | 3 | 17.65 | 3 | 3 | 0 | 0 | 0 | 0.00 |
a
The number and frequency of mutations in these genes that were seen in adenomas (AD) is listed. The mutation counts are subdivided into mutation types.
The mutation count and mutation frequency seen in MSS carcinomas (CA) for these genes are also listed. The specific mutations and their codon effects are listed in Supporting Information Table 2.