Table 4.
Frequently mutated genes in MSS carcinomas
| Gene | N a (%) | Total mutation | Missense | Nonsense | INDEL/frameshift | |
|---|---|---|---|---|---|---|
| (N = 16) | ||||||
| APC | 14 | 87.50 | 23 | 0 | 16 | 7 |
| TTN | 8 | 50.00 | 8 | 7 | 0 | 1 |
| OBSCN | 7 | 43.75 | 8 | 8 | 0 | 0 |
| KRAS | 7 | 43.75 | 7 | 7 | 0 | 0 |
| TP53 | 7 | 43.75 | 7 | 4 | 1 | 2 |
| PIK3CA | 4 | 25.00 | 4 | 4 | 0 | 0 |
| MYH6 | 3 | 18.75 | 4 | 4 | 0 | 0 |
| PXDN | 3 | 18.75 | 4 | 2 | 0 | 2 |
| TMEM132C | 3 | 18.75 | 4 | 3 | 1 | 0 |
| SOX9 | 3 | 18.75 | 3 | 0 | 0 | 3 |
| PAPLN | 3 | 18.75 | 3 | 3 | 0 | 0 |
a
The number and frequency of mutations in these genes that were seen in MSS carcinomas (CA) is listed.
The specific mutations and their codon effects are listed in Supporting Information Table 3.