Table 2.
Immunohistochemical findings of CTCL diagnosis.
| Case | Diagnosis | Main histological findings | CD2 | CD3 | CD4 | CD5 | CD7 | CD8 | CD30 | TIA-1 | EBER | BF1 | GM1 | CD4:CD8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CTCL NOS | Psoriasiform features with AL | N/A | + | + | + | + | − | N/A | 10% | N/A | + | 10% | 8:1 |
| 2 | CTCL NOS (large cells) | Spongiotic epidermis, superficial and mid dermis with AL | N/A | + | largecells | + | loss | − | 10% | − | − | + | − | 5:1 |
| 3 | CTCL NOS | Lobular panniculitis with AL | − | + | − | − | − | − | − | + | − | + | − | 4:1 |
| 4 | FMF | Folliculotropism of AL | N/A | + | + | − | N/A | N/A | 25% | N/A | N/A | + | − | 10:1 |
| 5 | FMF | Folliculotropism and syringotropism of AL | + | + | − | + | + | − | − | 3: 1 | ||||
| 6 | FMF | Folliculotropism of AL, psoriasiform features | N/A | + | + | N/A | N/A | N/A | − | N/A | N/A | N/A | N/A | 10:1 |
| 7 | FMF (LCT) | Folliculotropism with AL, psoriasiform features, large cells | N/A | + | + | N/A | 50% | − | + | − | N/A | N/A | N/A | 10:1 |
| 8 | MF | Band-like infiltrate with epidermotropism of AL | + | + | + | 50% | − | N/A | N/A | − | N/A | N/A | 5:1 | |
| 9 | MF | Band-like infiltrate with insterstitial AL | + | + | + | loss | loss | − | + | N/A | 10:1 | |||
| 10 | MF | Band-like infiltrate with epidermotropism of AL | N/A | + | + | + | N/A | N/A | few large cells | N/A | N/A | N/A | N/A | 7:1 |
| 11 | MF | Outside biopsy (N/A) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
| 12 | MF | Band-like infiltrate with epidermotropism of AL | − | + | + | − | − | − | 20% | − | − | − | − | 6: 1 |
| 13 | MF | Psoriasiform dermatitis with AL | N/A | + | + | + | − | − | N/A | N/A | N/A | + | N/A | 4:1 |
| 14 | MF (LCT) | Dense dermal infiltrate with syringotropism of large AL | − | + | + | + | − | − | 10% | − | N/A | N/A | N/A | N/A |
| 15 | MF (LCT) | Dense dermal infiltrate with large AL | + | + | + | + | N/A | − | + | N/A | N/A | N/A | N/A | |
| 16 | MF/LyP | Band-like infiltrate with epidermotropism of AL | + | − | + | − | + | − | 50% | N/A | N/A | N/A | N/A | 10:1 |
| 17 | PCAEC-TCL | Dense intraepidermal infiltrate of AL | − | + | − | + | − | − | scattered | + | − | − | − | N/A |
| 18 | PCγδTCL | Patchy infiltrate of AL in dermis and lobular panniculitis | + | + | − | − | − | − | + | + | − | − | − | N/A |
| 19 | SS | Psoriasiform features with AL | N/A | + | + | N/A | N/A | − | N/A | N/A | N/A | N/A | N/A | 10:1 |
| 20 | SS | Psoriasiform features with AL | Few+ | Few+ | + | + | − | − | − | N/A | N/A | + | − | 4:1 |
LCT: large cell transformation; N/A: non-available; AL: atypical lymphocytes