Table 2.

Enrichment test of the differentiation of trait-associated SNPs (clumped at P < 5 × 10⁻⁶) in the LD pattern against the control SNPs among the three populations in GERA and 1000G

Trait	GERA				1000G
	Associated SNPs		Control SNPs	P-value	Associated SNPs		Control SNPs	P-value
	Number of SNPs	Mean LDCV	Mean LDCV (s.d.)		Number of SNPs	Mean LDCV	Mean LDCV (s.d.)
Height	1044	0.401	0.376 (0.005)	2.01 × 10-6	1,099	0.390	0.373 (0.005)	1.99 × 10-4
BMI	157	0.402	0.375 (0.013)	0.037	179	0.400	0.38 (0.011)	0.089
WHRadjBMI	82	0.362	0.373 (0.019)	0.539	92	0.369	0.368 (0.016)	0.944
HDL	175	0.411	0.381 (0.014)	0.025	181	0.373	0.371 (0.012)	0.861
LDL	143	0.393	0.383 (0.015)	0.521	139	0.378	0.37 (0.013)	0.52
EAY	312	0.429	0.374 (0.01)	2.37 × 10-8	328	0.398	0.374 (0.008)	5.2 × 10-3
AD	43	0.413	0.388 (0.029)	0.397	46	0.407	0.367 (0.024)	0.093
CAD	101	0.402	0.383 (0.018)	0.289	102	0.389	0.367 (0.016)	0.164
SCZ	334	0.465	0.38 (0.01)	5.16 × 10-18	337	0.420	0.374 (0.008)	2.74 × 10-8
T2D	40	0.436	0.373 (0.028)	0.025	38	0.430	0.368 (0.024)	8.97 × 10-3

Bold values represent the results that are significant in GERA and replicated in 1000G, correcting for multiple tests