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. 2018 May 14;8:7522. doi: 10.1038/s41598-018-24982-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential mRNA expression analysis of AURKA knockdown in SW480 (A) and Caco2 (B) colorectal cancer cell lines. (A) and (B) Volcano plot of all unique genes from the differential mRNA expression analysis upon AURKA downmodulation for the SW480 and Caco2 cell lines, respectively. The vertical and horizontal lines illustrate the boundaries between significantly downregulated genes (red dots), significantly upregulated genes (blue dots) and non-significant differential genes (black dots). Horizontal lines represent the significance threshold of the q-value < 0.05. Vertical lines represent the significance threshold of the fold change 1.5 (log₂ fold change 0.58) up or down. C) VENN diagram of the number of significantly deregulated genes in SW480 and Caco2 (see Table 1). D) GO enrichment of the genes (n = 53) that are significantly deregulated in both cell lines in the same direction (the intersection in the Venn diagram in C minus one gene).