Table 1.
Genes significantly deregulated in both the Caco2 and SW480 cell lines under AURKA knockdown (n = 54).
| Gene ID | Gene name | SW480 | Caco2 | ||||
|---|---|---|---|---|---|---|---|
| p-value | q-value | FC** | p-value | q-value | FC** | ||
| AURKA | Aurora kinase A | 1.69e-6 | 1.86e-2 | −1.64 | 2.28e-7 | 1.96e-3 | −1.31 |
| REEP5 | Receptor accessory protein 5 | 2.20e-5 | 1.86e-2 | −1.24 | 1.83e-6 | 5.18e-3 | −0.97 |
| SLC12A2 | Solute carrier family 12 member 2 | 5.70e-6 | 1.86e-2 | −1.05 | 1.39e-5 | 6.82e-3 | 0.70 |
| DICER1 | Dicer 1, ribonuclease III | 1.94e-4 | 2.35e-2 | −1.02 | 6.79e-5 | 1.00e-2 | −0.75 |
| FEZ2 | Fasciculation and elongation protein zeta 2 | 7.41e-6 | 1.86e-2 | −0.99 | 7.61e-6 | 6.82e-3 | −0.70 |
| KRAS | KRAS proto-oncogene, GTPase | 9.58e-6 | 1.86e-2 | −0.95 | 1.10e-5 | 6.82e-3 | −0.65 |
| UBE2D1 | Ubiquitin conjugating enzyme E2 D1 | 3.08e-4 | 2.55e-2 | −0.92 | 1.08e-5 | 6.82e-3 | −0.91 |
| TM4SF1 | Transmembrane 4 L six family member 1 | 1.10e-4 | 2.28e-2 | −0.91 | 2.03e-5 | 7.98e-3 | −0.74 |
| ACVR1 | Activin A receptor type 1 | 2.60e-4 | 2.46e-2 | −0.87 | 6.36e-6 | 6.82e-3 | −0.99 |
| MARVELD2 | MARVEL domain containing 2 | 2.61e-5 | 1.86e-2 | −0.87 | 2.13e-5 | 7.98e-3 | −0.66 |
| BORCS8 | BLOC-1-related complex subunit 8 | 2.91e-5 | 1.86e-2 | −0.86 | 1.61e-5 | 7.31e-3 | −0.64 |
| SLC25A24 | Solute carrier family 25 member 24 | 5.87e-5 | 2.10e-2 | −0.85 | 1.10e-5 | 6.82e-3 | −0.71 |
| MBOAT2 | Membrane bound O-acyltransferase domain containing 2 | 1.73e-4 | 2.35e-2 | −0.76 | 7.00e-6 | 6.82e-3 | −0.84 |
| ACOX2 | Acyl-CoA oxidase 2 | 3.59e-5 | 1.86e-2 | −0.74 | 2.78e-5 | 8.77e-3 | −0.61 |
| TNFRSF11B | TNF receptor superfamily member 11b | 3.13e-5 | 1.86e-2 | −0.74 | 3.02e-7 | 1.96e-3 | −1.18 |
| NA* | ENSG00000260912* | 3.47e-3 | 4.91e-2 | −0.74 | 4.04e-5 | 9.30e-3 | −1.05 |
| NA* | ENSG00000234119* | 3.74e-5 | 1.91e-2 | −0.71 | 8.20e-6 | 6.82e-3 | −0.69 |
| SNX24 | Sorting nexin 24 | 2.46e-3 | 4.32e-2 | −0.70 | 5.16e-5 | 9.83e-3 | −0.86 |
| ANP32 A | Acidic nuclear phosphoprotein 32 family member A | 8.22e-5 | 2.26e-2 | −0.70 | 2.15e-5 | 7.98e-3 | −0.62 |
| CANX | Calnexin | 5.44e-4 | 2.89e-2 | −0.70 | 2.32e-6 | 5.52e-3 | −0.95 |
| TMX2P1 | Thioredoxin related transmembrane protein 2 pseudogene 1 | 2.87e-4 | 2.49e-2 | −0.70 | 5.42e-5 | 9.96e-3 | −0.63 |
| B4GALT4 | Beta-1,4-galactosyltransferase 4 | 8.17e-4 | 3.19e-2 | −0.68 | 3.53e-6 | 6.82e-3 | −1.17 |
| SNX4 | Sorting Nexin 4 | 1.09e-4 | 2.28e-2 | −0.67 | 4.74e-5 | 9.65e-3 | −0.61 |
| TSPYL4 | TSPY like 4 | 1.41e-4 | 2.35e-2 | −0.66 | 8.55e-6 | 6.82e-3 | −0.71 |
| PHLDA2 | Pleckstrin homology like domain family A member 2 | 1.67e-3 | 3.74e-2 | −0.60 | 4.19e-5 | 9.37e-3 | −0.61 |
| TP53I3 | Tumor protein p53 inducible protein 3 | 1.31e-4 | 2.35e-2 | −0.59 | 2.61e-5 | 8.77e-3 | −0.60 |
| ARHGAP19 | Rho GTPase activating protein 19 | 2.25e-4 | 2.37e-2 | 0.59 | 7.93e-6 | 6.82e-3 | 0.74 |
| LAMC1 | Laminin subunit gamma 1 | 6.03e-4 | 2.95e-2 | 0.60 | 6.01e-6 | 6.82e-3 | 0.96 |
| STK17B | Serine/threonine kinase 17b | 1.32e-3 | 3.54e-2 | 0.61 | 5.71e-5 | 1.00e-2 | 0.65 |
| NRP2 | Neuropilin 2 | 2.83e-3 | 4.55e-2 | 0.65 | 4.83e-5 | 9.65e-3 | 0.85 |
| IDNK | IDNK, gluconokinase | 2.18e-3 | 4.17e-2 | 0.67 | 2.16e-4 | 1.34e-2 | 0.62 |
| KTN1 | Kinetin 1 | 4.50e-5 | 2.05e-2 | 0.68 | 1.88e-5 | 7.93e-3 | 0.60 |
| RACGAP1 | Rac GTPase activating protein 1 | 2.77e-4 | 2.49e-2 | 0.72 | 6.11e-5 | 1.00e-2 | 0.65 |
| CDK6 | Cyclin dependent kinase 6 | 8.63e-5 | 2.26e-2 | 0.75 | 4.60e-6 | 6.82e-3 | 0.86 |
| SPA17 | Sperm autoantigenic protein 17 | 1.51e-4 | 2.35e-2 | 0.77 | 2.00e-5 | 7.98e-3 | 0.66 |
| LINC00467 | Long intergenic non-protein coding RNA 467 | 3.30e-5 | 1.86e-2 | 0.80 | 8.62e-6 | 6.82e-3 | 0.68 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 3.99e-5 | 1.94e-2 | 0.83 | 1.84e-5 | 7.89e-3 | 0.70 |
| BIK | BCL2 interacting killer | 3.11e-5 | 1.86e-2 | 0.86 | 2.01e-6 | 5.18e-3 | 0.87 |
| SH3D19 | SH3 domain containing 19 | 1.22e-4 | 2.35e-2 | 0.89 | 1.05e-5 | 6.82e-3 | 0.83 |
| EIF4EBP2 | Eukaryotic translation initiation factor 4E protein binding 2 | 7.50e-5 | 2.26e-2 | 0.92 | 2.09e-5 | 7.98e-3 | 0.72 |
| HMMR | Hyaluronan mediated motility receptor | 4.07e-5 | 1.95e-2 | 0.95 | 1.17e-5 | 6.82e-3 | 0.74 |
| KLHL15 | Kelch like family member 15 | 3.55e-4 | 2.64e-2 | 0.95 | 2.46e-4 | 1.42e-2 | 0.59 |
| DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2 | 4.09e-4 | 2.69e-2 | 0.97 | 3.68e-5 | 9.30e-3 | 0.80 |
| ZNF268 | Zink finger protein 268 | 3.95e-4 | 2.66e-2 | 0.98 | 8.72e-5 | 1.07e-2 | 0.67 |
| NUP98 | Nucleoporin 98 | 9.71e-6 | 1.86e-2 | 0.98 | 6.76e-6 | 6.82e-3 | 0.73 |
| MTMR6 | Myotubularin related protein 6 | 8.09e-4 | 3.19e-2 | 0.99 | 1.18e-4 | 1.20e-2 | 0.78 |
| PTP4A1 | Protein tyrosine phosphatase type IVA, member 1 | 5.08e-4 | 2.85e-2 | 1.04 | 1.94e-4 | 1.31e-2 | 0.80 |
| GOLT1B | Golgi transport 1B | 1.36e-5 | 1.86e-2 | 1.04 | 1.95e-5 | 7.98e-3 | 0.63 |
| RPS27L | Ribosomal protein S27 like | 6.91e-6 | 1.86e-2 | 1.05 | 1.06e-5 | 6.82e-3 | 0.67 |
| MALAT1 | Metastasis associated lung adenocarcinoma transcript 1 | 1.46e-3 | 3.66e-2 | 1.09 | 1.06e-5 | 6.82e-3 | 1.67 |
| LAMP2 | Lysosomal associated membrane protein 2 | 3.30e-4 | 2.62e-2 | 1.10 | 4.75e-5 | 9.65e-3 | 0.98 |
| SYPL1 | Synaptophysin like 1 | 5.69e-6 | 1.86e-2 | 1.11 | 5.63e-6 | 6.82e-3 | 0.73 |
| ARRDC4 | Arrestin domain containing 4 | 1.55e-3 | 3.70e-2 | 1.24 | 2.11e-3 | 3.15e-2 | 0.64 |
| MBNL1 | Muscleblind like splicing regulator 1 | 1.73e-6 | 1.86e-2 | 1.34 | 5.91e-6 | 6.82e-3 | 0.73 |
p-value, q-value and log2 fold change (FC) from the two differential mRNA expression analyses are shown for each gene ID. The Gene names are retrieved from Ensembl. The table is sorted on SW480 log2 FC. *Gene id and gene name are not available. The Ensembl id is provided as identifier. **FC = log2 fold change.