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. 2018 May 14;9:1866. doi: 10.1038/s41467-018-04322-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Disease course and immune response in patient UVM_IC. a Disease course since diagnosis. b Evolution of the GNAQ^Q209L mutation in circulating tumor DNA (ctDNA). c Computed tomography images at second relapse (14 months) and after 10 months of pembrolizumab (24 months). Arrows and circles show locations of metastases; asterisks indicate a simple hepatic cyst. d Proportions of blood effector memory CCR7⁻/CD45RA⁻/CD4⁺ and CCR7⁻/CD45RA⁺/CD8⁺ T-cells in 12 metastatic uveal melanoma patients treated with PD-1 inhibitors, including UVM_IC (red line)